Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy
Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks to a reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative trea...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/16/2/410 |
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| author | Santa Gabriella Bonaccorsi Thomas Tessonnier Line Hoeltgen Eva Meixner Semi Harrabi Juliane Hörner-Rieber Thomas Haberer Amir Abdollahi Jürgen Debus Andrea Mairani |
| author_facet | Santa Gabriella Bonaccorsi Thomas Tessonnier Line Hoeltgen Eva Meixner Semi Harrabi Juliane Hörner-Rieber Thomas Haberer Amir Abdollahi Jürgen Debus Andrea Mairani |
| author_sort | Santa Gabriella Bonaccorsi |
| collection | DOAJ |
| description | Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks to a reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative treatment planning study involving ten patients, previously treated with VMAT (Volumetric Modulated Arc Therapy) for 50 Gy in 25 fractions for locally advanced, node-positive breast cancer, was carried out using proton pencil beam therapy with a fixed relative biological effectiveness (RBE) of 1.1 and helium therapy with a variable RBE described by the mMKM (modified microdosimetric kinetic model). Results indicated that target coverage was improved with particle therapy for both the clinical target volume and especially the internal mammary lymph nodes compared to VMAT. Median dose value analysis revealed that proton and helium plans provided lower dose on the left anterior descending artery (LAD), heart, lungs and right breast than VMAT. Notably, helium therapy exhibited improved ipsilateral lung sparing over protons. Employing NTCP models as available in the literature, helium therapy showed a lower probability of grade ≤ 2 radiation pneumonitis (22% for photons, 5% for protons and 2% for helium ions), while both proton and helium ions reduce the probability of major coronary events with respect to VMAT. |
| first_indexed | 2024-03-08T11:01:47Z |
| format | Article |
| id | doaj.art-1481bb449d894fbfaaab57a36a0d1403 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T11:01:47Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-1481bb449d894fbfaaab57a36a0d14032024-01-26T15:37:49ZengMDPI AGCancers2072-66942024-01-0116241010.3390/cancers16020410Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer RadiotherapySanta Gabriella Bonaccorsi0Thomas Tessonnier1Line Hoeltgen2Eva Meixner3Semi Harrabi4Juliane Hörner-Rieber5Thomas Haberer6Amir Abdollahi7Jürgen Debus8Andrea Mairani9Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyDepartment of Radiation Oncology, Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg University Hospital, 69120 Heidelberg, GermanyProton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks to a reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative treatment planning study involving ten patients, previously treated with VMAT (Volumetric Modulated Arc Therapy) for 50 Gy in 25 fractions for locally advanced, node-positive breast cancer, was carried out using proton pencil beam therapy with a fixed relative biological effectiveness (RBE) of 1.1 and helium therapy with a variable RBE described by the mMKM (modified microdosimetric kinetic model). Results indicated that target coverage was improved with particle therapy for both the clinical target volume and especially the internal mammary lymph nodes compared to VMAT. Median dose value analysis revealed that proton and helium plans provided lower dose on the left anterior descending artery (LAD), heart, lungs and right breast than VMAT. Notably, helium therapy exhibited improved ipsilateral lung sparing over protons. Employing NTCP models as available in the literature, helium therapy showed a lower probability of grade ≤ 2 radiation pneumonitis (22% for photons, 5% for protons and 2% for helium ions), while both proton and helium ions reduce the probability of major coronary events with respect to VMAT.https://www.mdpi.com/2072-6694/16/2/410breast cancerleft-sided breast cancerradiation therapyparticle therapyproton therapyhelium therapy |
| spellingShingle | Santa Gabriella Bonaccorsi Thomas Tessonnier Line Hoeltgen Eva Meixner Semi Harrabi Juliane Hörner-Rieber Thomas Haberer Amir Abdollahi Jürgen Debus Andrea Mairani Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy Cancers breast cancer left-sided breast cancer radiation therapy particle therapy proton therapy helium therapy |
| title | Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy |
| title_full | Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy |
| title_fullStr | Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy |
| title_full_unstemmed | Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy |
| title_short | Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy |
| title_sort | exploring helium ions potential for post mastectomy left sided breast cancer radiotherapy |
| topic | breast cancer left-sided breast cancer radiation therapy particle therapy proton therapy helium therapy |
| url | https://www.mdpi.com/2072-6694/16/2/410 |
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