Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference
Introduction: The purpose of this study is to evaluate the diagnostic value of positron emission computed tomography-cone beam computed tomography (PET/CT-CBCT) fusion guided percutaneous biopsy, targeted to the maximum standardized uptake value (SUVmax) and minimum standardized uptake value (SUVmin...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-04-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221144508 |
| _version_ | 1797837283948232704 |
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| author | Filippo Piacentino MD, PhD Federico Fontana MD Giada Zorzetto MD Angiola Saccomanno MD Sabrina Casagrande MD Francesca Franzi MD Andrea Imperatori MD Carolina Lanza MD Serena Carriero MD Andrea Coppola MD Anna Maria Ierardi MD Gianpaolo Carrafiello MD Massimo Venturini MD |
| author_facet | Filippo Piacentino MD, PhD Federico Fontana MD Giada Zorzetto MD Angiola Saccomanno MD Sabrina Casagrande MD Francesca Franzi MD Andrea Imperatori MD Carolina Lanza MD Serena Carriero MD Andrea Coppola MD Anna Maria Ierardi MD Gianpaolo Carrafiello MD Massimo Venturini MD |
| author_sort | Filippo Piacentino MD, PhD |
| collection | DOAJ |
| description | Introduction: The purpose of this study is to evaluate the diagnostic value of positron emission computed tomography-cone beam computed tomography (PET/CT-CBCT) fusion guided percutaneous biopsy, targeted to the maximum standardized uptake value (SUVmax) and minimum standardized uptake value (SUVmin) of large lung lesions. Materials and Methods: Inside a larger cohort of PET/CT-CBCT guided percutaneous lung biopsies, 10 patients with large pulmonary lesions (diameter > 30 mm) were selected retrospectively. These patients have been subjected to double biopsy sampling respectively in the SUVmax area and in the SUVmin area of the lesion. Technical success has been calculated. For each sample, the percentage of neoplastic, inflammatory, and fibrotic cells was reported. Furthermore, the possibility of performing immunohistochemical or molecular biology investigations to specifically define the biomolecular tumor profile was analyzed. Results: Nine lesions were found to be malignant, one benign (inflammation). Technical success was 100% (10/10) in the SUVmax samples and 70% (7/10) in the SUVmin samples ( P-value: .21 ). In the first group, higher percentages of neoplastic cells were found at pathologic evaluation, while in the second group areas of inflammation and fibrosis were more represented. The biomolecular profile was obtained in 100% of cases (9/9) of the first group, while in the second group only in 33.3% of cases (2/6), with a statistically significant difference between the 2 groups ( P-value: .011 ). Conclusion: A correlation between the standardized uptake value value and the technical success of the biopsy sample has been identified. PET/CT-CBCT guidance allows to target the biopsy in the areas of the tumor which are richer in neoplastic cells, thus obtaining more useful information for the planning of patient-tailored cancer treatments. |
| first_indexed | 2024-04-09T15:22:13Z |
| format | Article |
| id | doaj.art-1483b515a50a49a394d7b4bba4e95142 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-09T15:22:13Z |
| publishDate | 2023-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-1483b515a50a49a394d7b4bba4e951422023-04-29T02:03:19ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382023-04-012210.1177/15330338221144508Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a DifferenceFilippo Piacentino MD, PhD0Federico Fontana MD1Giada Zorzetto MD2Angiola Saccomanno MD3Sabrina Casagrande MD4Francesca Franzi MD5Andrea Imperatori MD6Carolina Lanza MD7Serena Carriero MD8Andrea Coppola MD9Anna Maria Ierardi MD10Gianpaolo Carrafiello MD11Massimo Venturini MD12 Department of Diagnostic and Interventional Radiology, Circolo Hospital and Macchi Foundation, Insubria University, Varese, Italy Department of Diagnostic and Interventional Radiology, Circolo Hospital and Macchi Foundation, Insubria University, Varese, Italy Postgraduate School of Radiodiagnostics, , Varese, Italy Postgraduate School of Radiodiagnostics, , Varese, Italy Nuclear Medicine Unit, Circolo Hospital and Macchi Foundation, Varese, Italy Division of Pathological Anatomy, Circolo Hospital and Macchi Foundation, , Varese, Italy Division of Thoracic Surgery, Circolo Hospital and Macchi Foundation, , Varese, Italy Postgraduate School of Radiodiagnostics, Università degli Studi di Milano, Milan, Italy Postgraduate School of Radiodiagnostics, Università degli Studi di Milano, Milan, Italy Department of Diagnostic and Interventional Radiology, Circolo Hospital and Macchi Foundation, Insubria University, Varese, Italy Interventional Radiology Unit, Department of Radiology, Foundation IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy Interventional Radiology Unit, Department of Radiology, Foundation IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Milan, Italy Department of Diagnostic and Interventional Radiology, Circolo Hospital and Macchi Foundation, Insubria University, Varese, ItalyIntroduction: The purpose of this study is to evaluate the diagnostic value of positron emission computed tomography-cone beam computed tomography (PET/CT-CBCT) fusion guided percutaneous biopsy, targeted to the maximum standardized uptake value (SUVmax) and minimum standardized uptake value (SUVmin) of large lung lesions. Materials and Methods: Inside a larger cohort of PET/CT-CBCT guided percutaneous lung biopsies, 10 patients with large pulmonary lesions (diameter > 30 mm) were selected retrospectively. These patients have been subjected to double biopsy sampling respectively in the SUVmax area and in the SUVmin area of the lesion. Technical success has been calculated. For each sample, the percentage of neoplastic, inflammatory, and fibrotic cells was reported. Furthermore, the possibility of performing immunohistochemical or molecular biology investigations to specifically define the biomolecular tumor profile was analyzed. Results: Nine lesions were found to be malignant, one benign (inflammation). Technical success was 100% (10/10) in the SUVmax samples and 70% (7/10) in the SUVmin samples ( P-value: .21 ). In the first group, higher percentages of neoplastic cells were found at pathologic evaluation, while in the second group areas of inflammation and fibrosis were more represented. The biomolecular profile was obtained in 100% of cases (9/9) of the first group, while in the second group only in 33.3% of cases (2/6), with a statistically significant difference between the 2 groups ( P-value: .011 ). Conclusion: A correlation between the standardized uptake value value and the technical success of the biopsy sample has been identified. PET/CT-CBCT guidance allows to target the biopsy in the areas of the tumor which are richer in neoplastic cells, thus obtaining more useful information for the planning of patient-tailored cancer treatments.https://doi.org/10.1177/15330338221144508 |
| spellingShingle | Filippo Piacentino MD, PhD Federico Fontana MD Giada Zorzetto MD Angiola Saccomanno MD Sabrina Casagrande MD Francesca Franzi MD Andrea Imperatori MD Carolina Lanza MD Serena Carriero MD Andrea Coppola MD Anna Maria Ierardi MD Gianpaolo Carrafiello MD Massimo Venturini MD Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference Technology in Cancer Research & Treatment |
| title | Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference |
| title_full | Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference |
| title_fullStr | Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference |
| title_full_unstemmed | Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference |
| title_short | Could Maximum SUV be Used as Imaging Guidance in Large Lung Lesions Biopsies? Double Sampling Under PET-CT/XperGuide Fusion Imaging in Inhomogeneous Lung Uptaking Lesions to Show That it can Make a Difference |
| title_sort | could maximum suv be used as imaging guidance in large lung lesions biopsies double sampling under pet ct xperguide fusion imaging in inhomogeneous lung uptaking lesions to show that it can make a difference |
| url | https://doi.org/10.1177/15330338221144508 |
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