Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults
Background Despite the protective effects of stromal cell-derived factor 1 (SDF-1) in stimulating muscle regeneration shown in experimental research, there is a lack of clinical studies linking circulating SDF-1 concentrations with muscle phenotypes. In order to elucidate the role of SDF-1 as a pote...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Endocrine Society
2023-12-01
|
| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2023-1783.pdf |
| _version_ | 1827393484182519808 |
|---|---|
| author | Sunghwan Ji Kyunggon Kim So Jeong Park Jin Young Lee Hee-Won Jung Hyun Ju Yoo Il-Young Jang Eunju Lee Ji Yeon Baek Beom-Jun Kim |
| author_facet | Sunghwan Ji Kyunggon Kim So Jeong Park Jin Young Lee Hee-Won Jung Hyun Ju Yoo Il-Young Jang Eunju Lee Ji Yeon Baek Beom-Jun Kim |
| author_sort | Sunghwan Ji |
| collection | DOAJ |
| description | Background Despite the protective effects of stromal cell-derived factor 1 (SDF-1) in stimulating muscle regeneration shown in experimental research, there is a lack of clinical studies linking circulating SDF-1 concentrations with muscle phenotypes. In order to elucidate the role of SDF-1 as a potential biomarker reflecting human muscle health, we investigated the association of plasma SDF-1 levels with sarcopenia in older adults. Methods This cross-sectional study included 97 community-dwelling participants who underwent a comprehensive geriatric assessment at a tertiary hospital in South Korea. Sarcopenia was defined by specific cutoff values applicable to the Asian population, whereas plasma SDF-1 levels were determined using an enzyme immunoassay. Results After accounting for sex, age, and body mass index, participants with sarcopenia and low muscle mass exhibited plasma SDF-1 levels that were 21.8% and 18.3% lower than those without these conditions, respectively (P=0.008 and P=0.009, respectively). Consistently, higher plasma SDF-1 levels exhibited a significant correlation with higher skeletal muscle mass index (SMI) and gait speed (both P=0.043), and the risk of sarcopenia and low muscle mass decreased by 58% and 55% per standard deviation increase in plasma SDF-1 levels, respectively (P=0.045 and P=0.030, respectively). Furthermore, participants in the highest SDF-1 tertile exhibited significantly higher SMI compared to those in the lowest tertile (P=0.012). Conclusion These findings clinically corroborate earlier experimental discoveries highlighting the muscle anabolic effects of SDF-1 and support the potential role of circulating SDF-1 as a biomarker reflecting human muscle health in older adults. |
| first_indexed | 2024-03-08T17:50:44Z |
| format | Article |
| id | doaj.art-1483bbca12874bf09589e641b061f9fd |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-03-08T17:50:44Z |
| publishDate | 2023-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-1483bbca12874bf09589e641b061f9fd2024-01-02T08:10:38ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782023-12-0138670170810.3803/EnM.2023.17832428Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian AdultsSunghwan Ji0Kyunggon Kim1So Jeong Park2Jin Young Lee3Hee-Won Jung4Hyun Ju Yoo5Il-Young Jang6Eunju Lee7Ji Yeon Baek8Beom-Jun Kim9 Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Geriatrics, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, KoreaBackground Despite the protective effects of stromal cell-derived factor 1 (SDF-1) in stimulating muscle regeneration shown in experimental research, there is a lack of clinical studies linking circulating SDF-1 concentrations with muscle phenotypes. In order to elucidate the role of SDF-1 as a potential biomarker reflecting human muscle health, we investigated the association of plasma SDF-1 levels with sarcopenia in older adults. Methods This cross-sectional study included 97 community-dwelling participants who underwent a comprehensive geriatric assessment at a tertiary hospital in South Korea. Sarcopenia was defined by specific cutoff values applicable to the Asian population, whereas plasma SDF-1 levels were determined using an enzyme immunoassay. Results After accounting for sex, age, and body mass index, participants with sarcopenia and low muscle mass exhibited plasma SDF-1 levels that were 21.8% and 18.3% lower than those without these conditions, respectively (P=0.008 and P=0.009, respectively). Consistently, higher plasma SDF-1 levels exhibited a significant correlation with higher skeletal muscle mass index (SMI) and gait speed (both P=0.043), and the risk of sarcopenia and low muscle mass decreased by 58% and 55% per standard deviation increase in plasma SDF-1 levels, respectively (P=0.045 and P=0.030, respectively). Furthermore, participants in the highest SDF-1 tertile exhibited significantly higher SMI compared to those in the lowest tertile (P=0.012). Conclusion These findings clinically corroborate earlier experimental discoveries highlighting the muscle anabolic effects of SDF-1 and support the potential role of circulating SDF-1 as a biomarker reflecting human muscle health in older adults.http://www.e-enm.org/upload/pdf/enm-2023-1783.pdfsarcopeniastromal cell-derived factor 1chemokinesbiomarkersmuscle mass |
| spellingShingle | Sunghwan Ji Kyunggon Kim So Jeong Park Jin Young Lee Hee-Won Jung Hyun Ju Yoo Il-Young Jang Eunju Lee Ji Yeon Baek Beom-Jun Kim Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults Endocrinology and Metabolism sarcopenia stromal cell-derived factor 1 chemokines biomarkers muscle mass |
| title | Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults |
| title_full | Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults |
| title_fullStr | Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults |
| title_full_unstemmed | Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults |
| title_short | Higher Plasma Stromal Cell-Derived Factor 1 Is Associated with Lower Risk for Sarcopenia in Older Asian Adults |
| title_sort | higher plasma stromal cell derived factor 1 is associated with lower risk for sarcopenia in older asian adults |
| topic | sarcopenia stromal cell-derived factor 1 chemokines biomarkers muscle mass |
| url | http://www.e-enm.org/upload/pdf/enm-2023-1783.pdf |
| work_keys_str_mv | AT sunghwanji higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT kyunggonkim higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT sojeongpark higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT jinyounglee higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT heewonjung higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT hyunjuyoo higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT ilyoungjang higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT eunjulee higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT jiyeonbaek higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults AT beomjunkim higherplasmastromalcellderivedfactor1isassociatedwithlowerriskforsarcopeniainolderasianadults |