Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh
Influenza virological surveillance was conducted in Bangladesh from January to December 2021 in live poultry markets (LPMs) and in Tanguar Haor, a wetland region where domestic ducks have frequent contact with migratory birds. The predominant viruses circulating in LPMs were low pathogenic avian inf...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2252510 |
| _version_ | 1827211444462026752 |
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| author | Subrata Barman Jasmine C. M. Turner M. Kamrul Hasan Sharmin Akhtar Trushar Jeevan John Franks David Walker Nabanita Mukherjee Patrick Seiler Lisa Kercher Pamela McKenzie Robert G. Webster Mohammed M. Feeroz Richard J. Webby |
| author_facet | Subrata Barman Jasmine C. M. Turner M. Kamrul Hasan Sharmin Akhtar Trushar Jeevan John Franks David Walker Nabanita Mukherjee Patrick Seiler Lisa Kercher Pamela McKenzie Robert G. Webster Mohammed M. Feeroz Richard J. Webby |
| author_sort | Subrata Barman |
| collection | DOAJ |
| description | Influenza virological surveillance was conducted in Bangladesh from January to December 2021 in live poultry markets (LPMs) and in Tanguar Haor, a wetland region where domestic ducks have frequent contact with migratory birds. The predominant viruses circulating in LPMs were low pathogenic avian influenza (LPAI) H9N2 and clade 2.3.2.1a highly pathogenic avian influenza (HPAI) H5N1 viruses. Additional LPAIs were found in both LPM (H4N6) and Tanguar Haor wetlands (H7N7). Genetic analyses of these LPAIs strongly suggested long-distance movement of viruses along the Central Asian migratory bird flyway. We also detected a novel clade 2.3.4.4b H5N1 virus from ducks in free-range farms in Tanguar Haor that was similar to viruses first detected in October 2020 in The Netherlands but with a different PB2. Identification of clade 2.3.4.4b HPAI H5N1 viruses in Tanguar Haor provides continued support of the role of migratory birds in transboundary movement of influenza A viruses (IAV), including HPAI viruses. Domestic ducks in free range farm in wetland areas, like Tangua Haor, serve as a conduit for the introduction of LPAI and HPAI viruses into Bangladesh. Clade 2.3.4.4b viruses have dominated in many regions of the world since mid-2021, and it remains to be seen if these viruses will replace the endemic clade 2.3.2.1a H5N1 viruses in Bangladesh. |
| first_indexed | 2024-03-08T11:51:03Z |
| format | Article |
| id | doaj.art-148559173a004325896f6af0ad8af14f |
| institution | Directory Open Access Journal |
| issn | 2222-1751 |
| language | English |
| last_indexed | 2025-03-21T13:43:45Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj.art-148559173a004325896f6af0ad8af14f2024-06-26T10:39:28ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112210.1080/22221751.2023.2252510Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in BangladeshSubrata Barman0Jasmine C. M. Turner1M. Kamrul Hasan2Sharmin Akhtar3Trushar Jeevan4John Franks5David Walker6Nabanita Mukherjee7Patrick Seiler8Lisa Kercher9Pamela McKenzie10Robert G. Webster11Mohammed M. Feeroz12Richard J. Webby13Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Zoology, Jahangirnagar University, Dhaka, BangladeshDepartment of Zoology, Jahangirnagar University, Dhaka, BangladeshDepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USADepartment of Zoology, Jahangirnagar University, Dhaka, BangladeshDepartment of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USAInfluenza virological surveillance was conducted in Bangladesh from January to December 2021 in live poultry markets (LPMs) and in Tanguar Haor, a wetland region where domestic ducks have frequent contact with migratory birds. The predominant viruses circulating in LPMs were low pathogenic avian influenza (LPAI) H9N2 and clade 2.3.2.1a highly pathogenic avian influenza (HPAI) H5N1 viruses. Additional LPAIs were found in both LPM (H4N6) and Tanguar Haor wetlands (H7N7). Genetic analyses of these LPAIs strongly suggested long-distance movement of viruses along the Central Asian migratory bird flyway. We also detected a novel clade 2.3.4.4b H5N1 virus from ducks in free-range farms in Tanguar Haor that was similar to viruses first detected in October 2020 in The Netherlands but with a different PB2. Identification of clade 2.3.4.4b HPAI H5N1 viruses in Tanguar Haor provides continued support of the role of migratory birds in transboundary movement of influenza A viruses (IAV), including HPAI viruses. Domestic ducks in free range farm in wetland areas, like Tangua Haor, serve as a conduit for the introduction of LPAI and HPAI viruses into Bangladesh. Clade 2.3.4.4b viruses have dominated in many regions of the world since mid-2021, and it remains to be seen if these viruses will replace the endemic clade 2.3.2.1a H5N1 viruses in Bangladesh.https://www.tandfonline.com/doi/10.1080/22221751.2023.2252510Surveillanceavian influenza A virusclade 2.3.4.4b H5N1migratory birdsreassortmentdomestic ducks |
| spellingShingle | Subrata Barman Jasmine C. M. Turner M. Kamrul Hasan Sharmin Akhtar Trushar Jeevan John Franks David Walker Nabanita Mukherjee Patrick Seiler Lisa Kercher Pamela McKenzie Robert G. Webster Mohammed M. Feeroz Richard J. Webby Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh Emerging Microbes and Infections Surveillance avian influenza A virus clade 2.3.4.4b H5N1 migratory birds reassortment domestic ducks |
| title | Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh |
| title_full | Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh |
| title_fullStr | Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh |
| title_full_unstemmed | Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh |
| title_short | Emergence of a new genotype of clade 2.3.4.4b H5N1 highly pathogenic avian influenza A viruses in Bangladesh |
| title_sort | emergence of a new genotype of clade 2 3 4 4b h5n1 highly pathogenic avian influenza a viruses in bangladesh |
| topic | Surveillance avian influenza A virus clade 2.3.4.4b H5N1 migratory birds reassortment domestic ducks |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2252510 |
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