Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.
The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-12-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009190&type=printable |
| _version_ | 1826574378100326400 |
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| author | Anna L Swan Christine Schütt Jan Rozman Maria Del Mar Muñiz Moreno Stefan Brandmaier Michelle Simon Stefanie Leuchtenberger Mark Griffiths Robert Brommage Piia Keskivali-Bond Harald Grallert Thomas Werner Raffaele Teperino Lore Becker Gregor Miller Ala Moshiri John R Seavitt Derek D Cissell Terrence F Meehan Elif F Acar Christopher J Lelliott Ann M Flenniken Marie-France Champy Tania Sorg Abdel Ayadi Robert E Braun Heather Cater Mary E Dickinson Paul Flicek Juan Gallegos Elena J Ghirardello Jason D Heaney Sylvie Jacquot Connor Lally John G Logan Lydia Teboul Jeremy Mason Nadine Spielmann Colin McKerlie Stephen A Murray Lauryl M J Nutter Kristian F Odfalk Helen Parkinson Jan Prochazka Corey L Reynolds Mohammed Selloum Frantisek Spoutil Karen L Svenson Taylor S Vales Sara E Wells Jacqueline K White Radislav Sedlacek Wolfgang Wurst K C Kent Lloyd Peter I Croucher Helmut Fuchs Graham R Williams J H Duncan Bassett Valerie Gailus-Durner Yann Herault Ann-Marie Mallon Steve D M Brown Philipp Mayer-Kuckuk Martin Hrabe de Angelis IMPC Consortium |
| author_facet | Anna L Swan Christine Schütt Jan Rozman Maria Del Mar Muñiz Moreno Stefan Brandmaier Michelle Simon Stefanie Leuchtenberger Mark Griffiths Robert Brommage Piia Keskivali-Bond Harald Grallert Thomas Werner Raffaele Teperino Lore Becker Gregor Miller Ala Moshiri John R Seavitt Derek D Cissell Terrence F Meehan Elif F Acar Christopher J Lelliott Ann M Flenniken Marie-France Champy Tania Sorg Abdel Ayadi Robert E Braun Heather Cater Mary E Dickinson Paul Flicek Juan Gallegos Elena J Ghirardello Jason D Heaney Sylvie Jacquot Connor Lally John G Logan Lydia Teboul Jeremy Mason Nadine Spielmann Colin McKerlie Stephen A Murray Lauryl M J Nutter Kristian F Odfalk Helen Parkinson Jan Prochazka Corey L Reynolds Mohammed Selloum Frantisek Spoutil Karen L Svenson Taylor S Vales Sara E Wells Jacqueline K White Radislav Sedlacek Wolfgang Wurst K C Kent Lloyd Peter I Croucher Helmut Fuchs Graham R Williams J H Duncan Bassett Valerie Gailus-Durner Yann Herault Ann-Marie Mallon Steve D M Brown Philipp Mayer-Kuckuk Martin Hrabe de Angelis IMPC Consortium |
| author_sort | Anna L Swan |
| collection | DOAJ |
| description | The genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored BMD pathways, including vesicle transport, in these cells and together with in silico bone turnover studies resulted in the prioritization of candidate genes for further investigation. Overall, the results add novel pathophysiological and molecular insight into bone health and disease. |
| first_indexed | 2024-04-14T04:24:48Z |
| format | Article |
| id | doaj.art-14895730ccd5432c954b9d406684a8d3 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2025-03-14T12:57:51Z |
| publishDate | 2020-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-14895730ccd5432c954b9d406684a8d32025-03-02T05:31:40ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042020-12-011612e100919010.1371/journal.pgen.1009190Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density.Anna L SwanChristine SchüttJan RozmanMaria Del Mar Muñiz MorenoStefan BrandmaierMichelle SimonStefanie LeuchtenbergerMark GriffithsRobert BrommagePiia Keskivali-BondHarald GrallertThomas WernerRaffaele TeperinoLore BeckerGregor MillerAla MoshiriJohn R SeavittDerek D CissellTerrence F MeehanElif F AcarChristopher J LelliottAnn M FlennikenMarie-France ChampyTania SorgAbdel AyadiRobert E BraunHeather CaterMary E DickinsonPaul FlicekJuan GallegosElena J GhirardelloJason D HeaneySylvie JacquotConnor LallyJohn G LoganLydia TeboulJeremy MasonNadine SpielmannColin McKerlieStephen A MurrayLauryl M J NutterKristian F OdfalkHelen ParkinsonJan ProchazkaCorey L ReynoldsMohammed SelloumFrantisek SpoutilKaren L SvensonTaylor S ValesSara E WellsJacqueline K WhiteRadislav SedlacekWolfgang WurstK C Kent LloydPeter I CroucherHelmut FuchsGraham R WilliamsJ H Duncan BassettValerie Gailus-DurnerYann HeraultAnn-Marie MallonSteve D M BrownPhilipp Mayer-KuckukMartin Hrabe de AngelisIMPC ConsortiumThe genetic landscape of diseases associated with changes in bone mineral density (BMD), such as osteoporosis, is only partially understood. Here, we explored data from 3,823 mutant mouse strains for BMD, a measure that is frequently altered in a range of bone pathologies, including osteoporosis. A total of 200 genes were found to significantly affect BMD. This pool of BMD genes comprised 141 genes with previously unknown functions in bone biology and was complementary to pools derived from recent human studies. Nineteen of the 141 genes also caused skeletal abnormalities. Examination of the BMD genes in osteoclasts and osteoblasts underscored BMD pathways, including vesicle transport, in these cells and together with in silico bone turnover studies resulted in the prioritization of candidate genes for further investigation. Overall, the results add novel pathophysiological and molecular insight into bone health and disease.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009190&type=printable |
| spellingShingle | Anna L Swan Christine Schütt Jan Rozman Maria Del Mar Muñiz Moreno Stefan Brandmaier Michelle Simon Stefanie Leuchtenberger Mark Griffiths Robert Brommage Piia Keskivali-Bond Harald Grallert Thomas Werner Raffaele Teperino Lore Becker Gregor Miller Ala Moshiri John R Seavitt Derek D Cissell Terrence F Meehan Elif F Acar Christopher J Lelliott Ann M Flenniken Marie-France Champy Tania Sorg Abdel Ayadi Robert E Braun Heather Cater Mary E Dickinson Paul Flicek Juan Gallegos Elena J Ghirardello Jason D Heaney Sylvie Jacquot Connor Lally John G Logan Lydia Teboul Jeremy Mason Nadine Spielmann Colin McKerlie Stephen A Murray Lauryl M J Nutter Kristian F Odfalk Helen Parkinson Jan Prochazka Corey L Reynolds Mohammed Selloum Frantisek Spoutil Karen L Svenson Taylor S Vales Sara E Wells Jacqueline K White Radislav Sedlacek Wolfgang Wurst K C Kent Lloyd Peter I Croucher Helmut Fuchs Graham R Williams J H Duncan Bassett Valerie Gailus-Durner Yann Herault Ann-Marie Mallon Steve D M Brown Philipp Mayer-Kuckuk Martin Hrabe de Angelis IMPC Consortium Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. PLoS Genetics |
| title | Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. |
| title_full | Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. |
| title_fullStr | Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. |
| title_full_unstemmed | Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. |
| title_short | Mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density. |
| title_sort | mouse mutant phenotyping at scale reveals novel genes controlling bone mineral density |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1009190&type=printable |
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