Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF

Targeting GGT1 Eliminates the Tumor-Promoting Effect and Enhanced Immunosuppressive Function of Myeloid-Derived Suppressor Cells Caused by G-CSF

Myeloid-derived suppressor cells (MDSCs) are major immunosuppressive cells that accumulate in tumor-bearing hosts. Since MDSCs suppress anti-tumor immunity and promote tumor progression, they are promising targets for cancer immunotherapy. Granulocyte colony-stimulating factor (G-CSF) is an agent us...

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Bibliographic Details
Main Authors: Zhiqi Xie, Takahiro Kawasaki, Haoyang Zhou, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
myeloid-derived suppressor cells
granulocyte colony-stimulating factor
GGT1
febrile neutropenia
GGsTop
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.873792/full

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