Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2.
Escherichia coli strain O157:H7 is a major cause of food poisoning that can result in severe diarrhea and, in some cases, renal failure. The pathogenesis of E. coli O157:H7 is in large part due to the production of Shiga toxin (Stx), an AB(5) toxin that consists of a ribosomal RNA-cleaving A-subunit...
Main Authors: | Deborah G Conrady, Michael J Flagler, David R Friedmann, Bradley D Vander Wielen, Rhett A Kovall, Alison A Weiss, Andrew B Herr |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-12-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3010993?pdf=render |
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