Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease
Siyao Wang,1 Yong Zhang,1,2 Xiaoya Qi,1 Xiaoyang Xu1 1Health Medicine Center, The Second Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China; 2School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Xiaoyang X...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Jezik: | English |
| Izdano: |
Dove Medical Press
2024-05-01
|
| Serija: | Diabetes, Metabolic Syndrome and Obesity |
| Teme: | |
| Online dostop: | https://www.dovepress.com/cardiometabolic-and-metabolic-profiles-of-leannormal-overweight-and-ob-peer-reviewed-fulltext-article-DMSO |
| _version_ | 1831889080139382784 |
|---|---|
| author | Wang S Zhang Y Qi X Xu X |
| author_facet | Wang S Zhang Y Qi X Xu X |
| author_sort | Wang S |
| collection | DOAJ |
| description | Siyao Wang,1 Yong Zhang,1,2 Xiaoya Qi,1 Xiaoyang Xu1 1Health Medicine Center, The Second Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China; 2School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Xiaoyang Xu, Health Medicine Center, The Second Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China, Email 302500@hospital.cqmu.edu.cnPurpose: Disagreements about the risk of non-obese, non-alcoholic fatty liver disease for cardiometabolic outcomes occurred widely. This study aims to characterize the cardiometabolic and metabolic profile of lean/normal, overweight and obese patients with nonalcoholic fatty liver disease on a big sample.Patients and methods: Appeared healthy adults who participated in health examinations during the year of 2019– 2022 were screened for fatty liver diagnosis. BMI classified fatty livers as lean, overweight and obese. Eleven cardiometabolic metrics (SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol) and metabolic metrics (GLU: blood glucose; GHB: glycated haemoglobin; UA: uric acid; AST: aspartate aminotransferase; ALT: alanine aminotransferase) were included, described and compared among BMI categories.Results: There were 56,496 fatty livers diagnosed by ultrasound in this study. In total, the lean fatty liver had lowest mean SBP, DBP, GLU, TG, UA, AST, and ALT but highest TC and HDL among BMI categories (all p < 0.001). The number of abnormal metrics in total was 2.5, 2.9 and 3.4 in lean, overweight, and obesity, respectively (p < 0.001, p_trend < 0.001). Visualized data showed that lean fatty liver was similar but milder in all metabolic metrics than overweight and obesity at the young ages. However, lean fatty liver had higher coefficients of age and risk of metabolic abnormality regression (p < 0.001 for SBP, DBP, GLU, GHB, TC).Conclusion: The lean type of fatty livers at a younger age has a relatively favourable cardiometabolic and metabolic profile compared to overweight and obese fatty livers. Due to the possible catch-up effect of metabolic dysfunctions in young lean fatty liver, lean fatty liver may have the same health outcomes as overweight/obesity fatty liver in long term. The evaluation and intervention may be critical for young lean fatty liver management to slowdown the rapid progress of metabolic dysfunction.Keywords: fatty liver, cardiometabolic profile, metabolic profile, body mass index |
| first_indexed | 2025-03-22T00:29:23Z |
| format | Article |
| id | doaj.art-148adf7f656b458b9888b8c20b9ff6dc |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2025-03-22T00:29:23Z |
| publishDate | 2024-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-148adf7f656b458b9888b8c20b9ff6dc2024-05-14T18:02:14ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072024-05-01Volume 172027203692602Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver DiseaseWang SZhang YQi XXu XSiyao Wang,1 Yong Zhang,1,2 Xiaoya Qi,1 Xiaoyang Xu1 1Health Medicine Center, The Second Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China; 2School of Public Health, Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Xiaoyang Xu, Health Medicine Center, The Second Hospital Affiliated to Chongqing Medical University, Chongqing, People’s Republic of China, Email 302500@hospital.cqmu.edu.cnPurpose: Disagreements about the risk of non-obese, non-alcoholic fatty liver disease for cardiometabolic outcomes occurred widely. This study aims to characterize the cardiometabolic and metabolic profile of lean/normal, overweight and obese patients with nonalcoholic fatty liver disease on a big sample.Patients and methods: Appeared healthy adults who participated in health examinations during the year of 2019– 2022 were screened for fatty liver diagnosis. BMI classified fatty livers as lean, overweight and obese. Eleven cardiometabolic metrics (SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglycerides; HDL: high-density lipoprotein cholesterol; LDL: low-density lipoprotein cholesterol) and metabolic metrics (GLU: blood glucose; GHB: glycated haemoglobin; UA: uric acid; AST: aspartate aminotransferase; ALT: alanine aminotransferase) were included, described and compared among BMI categories.Results: There were 56,496 fatty livers diagnosed by ultrasound in this study. In total, the lean fatty liver had lowest mean SBP, DBP, GLU, TG, UA, AST, and ALT but highest TC and HDL among BMI categories (all p < 0.001). The number of abnormal metrics in total was 2.5, 2.9 and 3.4 in lean, overweight, and obesity, respectively (p < 0.001, p_trend < 0.001). Visualized data showed that lean fatty liver was similar but milder in all metabolic metrics than overweight and obesity at the young ages. However, lean fatty liver had higher coefficients of age and risk of metabolic abnormality regression (p < 0.001 for SBP, DBP, GLU, GHB, TC).Conclusion: The lean type of fatty livers at a younger age has a relatively favourable cardiometabolic and metabolic profile compared to overweight and obese fatty livers. Due to the possible catch-up effect of metabolic dysfunctions in young lean fatty liver, lean fatty liver may have the same health outcomes as overweight/obesity fatty liver in long term. The evaluation and intervention may be critical for young lean fatty liver management to slowdown the rapid progress of metabolic dysfunction.Keywords: fatty liver, cardiometabolic profile, metabolic profile, body mass indexhttps://www.dovepress.com/cardiometabolic-and-metabolic-profiles-of-leannormal-overweight-and-ob-peer-reviewed-fulltext-article-DMSOfatty livercardiometabolic profilemetabolic profilebody mass index |
| spellingShingle | Wang S Zhang Y Qi X Xu X Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease Diabetes, Metabolic Syndrome and Obesity fatty liver cardiometabolic profile metabolic profile body mass index |
| title | Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease |
| title_full | Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease |
| title_fullStr | Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease |
| title_full_unstemmed | Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease |
| title_short | Cardiometabolic and Metabolic Profiles of Lean/Normal, Overweight and Obese Patients with Nonalcoholic Fatty Liver Disease |
| title_sort | cardiometabolic and metabolic profiles of lean normal overweight and obese patients with nonalcoholic fatty liver disease |
| topic | fatty liver cardiometabolic profile metabolic profile body mass index |
| url | https://www.dovepress.com/cardiometabolic-and-metabolic-profiles-of-leannormal-overweight-and-ob-peer-reviewed-fulltext-article-DMSO |
| work_keys_str_mv | AT wangs cardiometabolicandmetabolicprofilesofleannormaloverweightandobesepatientswithnonalcoholicfattyliverdisease AT zhangy cardiometabolicandmetabolicprofilesofleannormaloverweightandobesepatientswithnonalcoholicfattyliverdisease AT qix cardiometabolicandmetabolicprofilesofleannormaloverweightandobesepatientswithnonalcoholicfattyliverdisease AT xux cardiometabolicandmetabolicprofilesofleannormaloverweightandobesepatientswithnonalcoholicfattyliverdisease |