CDC42—A promising immune-related target in glioma
Glioma is the worst prognostic neoplasm in the central nervous system. A polarity-regulating GTPase in cells, known as cell division cycle 42 (CdC42), has been proven to have its overactivation tightly connected to high tumor malignancy. The RNA-seq and protein expression of CDC42 in tumor and compa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2023.1192766/full |
| _version_ | 1797786821745180672 |
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| author | Tao Jiang Tao Jiang Xianwei Wang Jiaming Huang Dong Chen Dong Chen |
| author_facet | Tao Jiang Tao Jiang Xianwei Wang Jiaming Huang Dong Chen Dong Chen |
| author_sort | Tao Jiang |
| collection | DOAJ |
| description | Glioma is the worst prognostic neoplasm in the central nervous system. A polarity-regulating GTPase in cells, known as cell division cycle 42 (CdC42), has been proven to have its overactivation tightly connected to high tumor malignancy. The RNA-seq and protein expression of CDC42 in tumor and comparison tissues were analyzed based on the online tools; CDC42 was remarkably boosted in tumor tissues compared to normal controls. A total of 600 patients in the analysis set from The Cancer Genome Atlas (TCGA) database and 657 patients in the validation set from the Chinese Glioma Genome Atlas (CGGA) database were adopted. The expression of CDC42 in clinical features and biological functions of glioma was analyzed, including differential expression analysis, survival analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and immune infiltration analysis. The enrichment of CDC42 was shown to be strongly associated with poor prognosis and terrible clinical indexes of glioma, including higher World Health Organization scale grade, wild-type isocitrate dehydrogenase 1 expression, O6-methylguanine-DNA methyltransferase non-methylated status, and 1p19q non-codeletion status (p < 0.0001). Functional enrichment analysis showed that CDC42 was highly correlated with immune and inflammatory responses in glioma. Additionally, the concentration extent of CDC42 was closely related to immune infiltration, immune checkpoints, and regulatory T (Treg) cell markers (CD4, CD25, and CD127). All evidence suggested that CDC42 may be a potential target for glioma immunotherapy. |
| first_indexed | 2024-03-13T01:14:18Z |
| format | Article |
| id | doaj.art-148c48adc1734a10983784d1de5abab8 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-03-13T01:14:18Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-148c48adc1734a10983784d1de5abab82023-07-05T12:24:38ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2023-07-011710.3389/fnins.2023.11927661192766CDC42—A promising immune-related target in gliomaTao Jiang0Tao Jiang1Xianwei Wang2Jiaming Huang3Dong Chen4Dong Chen5Department of Neurosurgery, The Dalian Municipal Central Hospital, Dalian, ChinaDalian Municipal Central Hospital, China Medical University, Shenyang, ChinaDepartment of Neurosurgery, The Dalian Municipal Central Hospital, Dalian, ChinaDepartment of Neurosurgery, The Dalian Municipal Central Hospital, Dalian, ChinaDepartment of Neurosurgery, The Dalian Municipal Central Hospital, Dalian, ChinaDalian Municipal Central Hospital, China Medical University, Shenyang, ChinaGlioma is the worst prognostic neoplasm in the central nervous system. A polarity-regulating GTPase in cells, known as cell division cycle 42 (CdC42), has been proven to have its overactivation tightly connected to high tumor malignancy. The RNA-seq and protein expression of CDC42 in tumor and comparison tissues were analyzed based on the online tools; CDC42 was remarkably boosted in tumor tissues compared to normal controls. A total of 600 patients in the analysis set from The Cancer Genome Atlas (TCGA) database and 657 patients in the validation set from the Chinese Glioma Genome Atlas (CGGA) database were adopted. The expression of CDC42 in clinical features and biological functions of glioma was analyzed, including differential expression analysis, survival analysis, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, and immune infiltration analysis. The enrichment of CDC42 was shown to be strongly associated with poor prognosis and terrible clinical indexes of glioma, including higher World Health Organization scale grade, wild-type isocitrate dehydrogenase 1 expression, O6-methylguanine-DNA methyltransferase non-methylated status, and 1p19q non-codeletion status (p < 0.0001). Functional enrichment analysis showed that CDC42 was highly correlated with immune and inflammatory responses in glioma. Additionally, the concentration extent of CDC42 was closely related to immune infiltration, immune checkpoints, and regulatory T (Treg) cell markers (CD4, CD25, and CD127). All evidence suggested that CDC42 may be a potential target for glioma immunotherapy.https://www.frontiersin.org/articles/10.3389/fnins.2023.1192766/fullbioinformatics analysissurvival analysisimmune infiltrationCDC42glioma |
| spellingShingle | Tao Jiang Tao Jiang Xianwei Wang Jiaming Huang Dong Chen Dong Chen CDC42—A promising immune-related target in glioma Frontiers in Neuroscience bioinformatics analysis survival analysis immune infiltration CDC42 glioma |
| title | CDC42—A promising immune-related target in glioma |
| title_full | CDC42—A promising immune-related target in glioma |
| title_fullStr | CDC42—A promising immune-related target in glioma |
| title_full_unstemmed | CDC42—A promising immune-related target in glioma |
| title_short | CDC42—A promising immune-related target in glioma |
| title_sort | cdc42 a promising immune related target in glioma |
| topic | bioinformatics analysis survival analysis immune infiltration CDC42 glioma |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2023.1192766/full |
| work_keys_str_mv | AT taojiang cdc42apromisingimmunerelatedtargetinglioma AT taojiang cdc42apromisingimmunerelatedtargetinglioma AT xianweiwang cdc42apromisingimmunerelatedtargetinglioma AT jiaminghuang cdc42apromisingimmunerelatedtargetinglioma AT dongchen cdc42apromisingimmunerelatedtargetinglioma AT dongchen cdc42apromisingimmunerelatedtargetinglioma |