Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat
Background Recently it has been shown in animal studies that deep brain stimulation (DBS) of auditory structures was able to reduce tinnitus-like behavior. However, the question arises whether hearing might be impaired when interfering in auditory-related network loops with DBS. Methods The auditory...
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PeerJ Inc.
2017-10-01
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| Online Access: | https://peerj.com/articles/3892.pdf |
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| author | Jasper V. Smit Ali Jahanshahi Marcus L.F. Janssen Robert J. Stokroos Yasin Temel |
| author_facet | Jasper V. Smit Ali Jahanshahi Marcus L.F. Janssen Robert J. Stokroos Yasin Temel |
| author_sort | Jasper V. Smit |
| collection | DOAJ |
| description | Background Recently it has been shown in animal studies that deep brain stimulation (DBS) of auditory structures was able to reduce tinnitus-like behavior. However, the question arises whether hearing might be impaired when interfering in auditory-related network loops with DBS. Methods The auditory brainstem response (ABR) was measured in rats during high frequency stimulation (HFS) and low frequency stimulation (LFS) in the central nucleus of the inferior colliculus (CIC, n = 5) or dentate cerebellar nucleus (DCBN, n = 5). Besides hearing thresholds using ABR, relative measures of latency and amplitude can be extracted from the ABR. In this study ABR thresholds, interpeak latencies (I–III, III–V, I–V) and V/I amplitude ratio were measured during off-stimulation state and during LFS and HFS. Results In both the CIC and the CNBN groups, no significant differences were observed for all outcome measures. Discussion DBS in both the CIC and the CNBN did not have adverse effects on hearing measurements. These findings suggest that DBS does not hamper physiological processing in the auditory circuitry. |
| first_indexed | 2024-03-09T06:36:52Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T06:36:52Z |
| publishDate | 2017-10-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-148dac4faf41445ba9cf8631291889fa2023-12-03T10:56:38ZengPeerJ Inc.PeerJ2167-83592017-10-015e389210.7717/peerj.3892Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in ratJasper V. Smit0Ali Jahanshahi1Marcus L.F. Janssen2Robert J. Stokroos3Yasin Temel4Department of Ear Nose and Throat/Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The NetherlandsDepartment of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The NetherlandsDepartment of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The NetherlandsDepartment of Ear Nose and Throat/Head and Neck Surgery, Maastricht University Medical Center, Maastricht, The NetherlandsDepartment of Neuroscience, School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The NetherlandsBackground Recently it has been shown in animal studies that deep brain stimulation (DBS) of auditory structures was able to reduce tinnitus-like behavior. However, the question arises whether hearing might be impaired when interfering in auditory-related network loops with DBS. Methods The auditory brainstem response (ABR) was measured in rats during high frequency stimulation (HFS) and low frequency stimulation (LFS) in the central nucleus of the inferior colliculus (CIC, n = 5) or dentate cerebellar nucleus (DCBN, n = 5). Besides hearing thresholds using ABR, relative measures of latency and amplitude can be extracted from the ABR. In this study ABR thresholds, interpeak latencies (I–III, III–V, I–V) and V/I amplitude ratio were measured during off-stimulation state and during LFS and HFS. Results In both the CIC and the CNBN groups, no significant differences were observed for all outcome measures. Discussion DBS in both the CIC and the CNBN did not have adverse effects on hearing measurements. These findings suggest that DBS does not hamper physiological processing in the auditory circuitry.https://peerj.com/articles/3892.pdfDeep brain stimulationTinnitusDentate cerebellar nucleusHearing lossAuditory brainstem responseInferior colliculus |
| spellingShingle | Jasper V. Smit Ali Jahanshahi Marcus L.F. Janssen Robert J. Stokroos Yasin Temel Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat PeerJ Deep brain stimulation Tinnitus Dentate cerebellar nucleus Hearing loss Auditory brainstem response Inferior colliculus |
| title | Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| title_full | Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| title_fullStr | Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| title_full_unstemmed | Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| title_short | Hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| title_sort | hearing assessment during deep brain stimulation of the central nucleus of the inferior colliculus and dentate cerebellar nucleus in rat |
| topic | Deep brain stimulation Tinnitus Dentate cerebellar nucleus Hearing loss Auditory brainstem response Inferior colliculus |
| url | https://peerj.com/articles/3892.pdf |
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