Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing
During space flight, especially when prolonged, exposure to microgravity results in a number of pathophysiological changes such as bone loss, muscle atrophy, cardiovascular and metabolic changes and impaired wound healing, among others. Interestingly, chronic low-grade inflammation and insulin resis...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.868999/full |
| _version_ | 1811234425700089856 |
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| author | F. Strollo S. Gentile A. M. V. Pipicelli A. Mambro M. Monici P. Magni P. Magni |
| author_facet | F. Strollo S. Gentile A. M. V. Pipicelli A. Mambro M. Monici P. Magni P. Magni |
| author_sort | F. Strollo |
| collection | DOAJ |
| description | During space flight, especially when prolonged, exposure to microgravity results in a number of pathophysiological changes such as bone loss, muscle atrophy, cardiovascular and metabolic changes and impaired wound healing, among others. Interestingly, chronic low-grade inflammation and insulin resistance appear to be pivotal events linking many of them. Interestingly, real and experimental microgravity is also associated to altered wound repair, a process that is becoming increasingly important in view of prolonged space flights. The association of insulin resistance and wound healing impairment may be hypothesized from some dysmetabolic conditions, like the metabolic syndrome, type 2 diabetes mellitus and abdominal/visceral obesity, where derangement of glucose and lipid metabolism, greater low-grade inflammation, altered adipokine secretion and adipocyte dysfunction converge to produce systemic effects that also negatively involve wound healing. Indeed, wound healing impairment after traumatic events and surgery in space remains a relevant concern for space agencies. Further studies are required to clarify the molecular connection between insulin resistance and wound healing during space flight, addressing the ability of physical, endocrine/metabolic, and pharmacological countermeasures, as well as nutritional strategies to prevent long-term detrimental effects on tissue repair linked to insulin resistance. Based on these considerations, this paper discusses the pathophysiological links between microgravity-associated insulin resistance and impaired wound healing. |
| first_indexed | 2024-04-12T11:36:03Z |
| format | Article |
| id | doaj.art-148fd58d03d246f199d2910ca65b81cb |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T11:36:03Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-148fd58d03d246f199d2910ca65b81cb2022-12-22T03:34:49ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.868999868999Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound HealingF. Strollo0S. Gentile1A. M. V. Pipicelli2A. Mambro3M. Monici4P. Magni5P. Magni6Endocrinology and Metabolism Unit, IRCCS San Raffaele Pisana, Rome, ItalyDepartment of Internal Medicine, Campania University “Luigi Vanvitelli”, Naples, Italy and Nefrocenter Research Network, Naples, ItalyNephrology, Dialysis and Transplant Unit, Medical and Surgical Sciences Department, “A. Gemelli” Sacred Heart Catholic University, Rome, ItalyAnesthesiology and Intensive Care Unit, Pertini General Hospital, Rome, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, ASA Campus Joint Laboratory, ASA Res. Div, University of Florence, Florence, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università Degli Studi di Milano, Milan, ItalyIRCCS Multimedica Hospital, Sesto San Giovanni, Milan, ItalyDuring space flight, especially when prolonged, exposure to microgravity results in a number of pathophysiological changes such as bone loss, muscle atrophy, cardiovascular and metabolic changes and impaired wound healing, among others. Interestingly, chronic low-grade inflammation and insulin resistance appear to be pivotal events linking many of them. Interestingly, real and experimental microgravity is also associated to altered wound repair, a process that is becoming increasingly important in view of prolonged space flights. The association of insulin resistance and wound healing impairment may be hypothesized from some dysmetabolic conditions, like the metabolic syndrome, type 2 diabetes mellitus and abdominal/visceral obesity, where derangement of glucose and lipid metabolism, greater low-grade inflammation, altered adipokine secretion and adipocyte dysfunction converge to produce systemic effects that also negatively involve wound healing. Indeed, wound healing impairment after traumatic events and surgery in space remains a relevant concern for space agencies. Further studies are required to clarify the molecular connection between insulin resistance and wound healing during space flight, addressing the ability of physical, endocrine/metabolic, and pharmacological countermeasures, as well as nutritional strategies to prevent long-term detrimental effects on tissue repair linked to insulin resistance. Based on these considerations, this paper discusses the pathophysiological links between microgravity-associated insulin resistance and impaired wound healing.https://www.frontiersin.org/articles/10.3389/fbioe.2022.868999/fullinsulin resistancewound healingmicrogravityspaceflightrehabilitationdiabetes complications |
| spellingShingle | F. Strollo S. Gentile A. M. V. Pipicelli A. Mambro M. Monici P. Magni P. Magni Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing Frontiers in Bioengineering and Biotechnology insulin resistance wound healing microgravity spaceflight rehabilitation diabetes complications |
| title | Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing |
| title_full | Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing |
| title_fullStr | Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing |
| title_full_unstemmed | Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing |
| title_short | Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing |
| title_sort | space flight promoted insulin resistance as a possible disruptor of wound healing |
| topic | insulin resistance wound healing microgravity spaceflight rehabilitation diabetes complications |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.868999/full |
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