STAT3 Role in T-Cell Memory Formation
Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transc...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/5/2878 |
| _version_ | 1797474825000714240 |
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| author | Yaroslav Kaminskiy Jan Joseph Melenhorst |
| author_facet | Yaroslav Kaminskiy Jan Joseph Melenhorst |
| author_sort | Yaroslav Kaminskiy |
| collection | DOAJ |
| description | Along with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity. |
| first_indexed | 2024-03-09T20:35:37Z |
| format | Article |
| id | doaj.art-14903a45cdbc423c8e53eb25f97470b0 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T20:35:37Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-14903a45cdbc423c8e53eb25f97470b02023-11-23T23:11:08ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-03-01235287810.3390/ijms23052878STAT3 Role in T-Cell Memory FormationYaroslav Kaminskiy0Jan Joseph Melenhorst1Department of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USADepartment of Pathology and Laboratory Medicine, Center for Cellular Immunotherapies, University of Pennsylvania, Philadelphia, PA 19104, USAAlong with the clinical success of immuno-oncology drugs and cellular therapies, T-cell biology has attracted considerable attention in the immunology community. Long-term immunity, traditionally analyzed in the context of infection, is increasingly studied in cancer. Many signaling pathways, transcription factors, and metabolic regulators have been shown to participate in the formation of memory T cells. There is increasing evidence that the signal transducer and activator of transcription-3 (STAT3) signaling pathway is crucial for the formation of long-term T-cell immunity capable of efficient recall responses. In this review, we summarize what is currently known about STAT3 role in the context of memory T-cell formation and antitumor immunity.https://www.mdpi.com/1422-0067/23/5/2878STAT3T-cell differentiationimmune responseantitumor immunitycellular therapy |
| spellingShingle | Yaroslav Kaminskiy Jan Joseph Melenhorst STAT3 Role in T-Cell Memory Formation International Journal of Molecular Sciences STAT3 T-cell differentiation immune response antitumor immunity cellular therapy |
| title | STAT3 Role in T-Cell Memory Formation |
| title_full | STAT3 Role in T-Cell Memory Formation |
| title_fullStr | STAT3 Role in T-Cell Memory Formation |
| title_full_unstemmed | STAT3 Role in T-Cell Memory Formation |
| title_short | STAT3 Role in T-Cell Memory Formation |
| title_sort | stat3 role in t cell memory formation |
| topic | STAT3 T-cell differentiation immune response antitumor immunity cellular therapy |
| url | https://www.mdpi.com/1422-0067/23/5/2878 |
| work_keys_str_mv | AT yaroslavkaminskiy stat3roleintcellmemoryformation AT janjosephmelenhorst stat3roleintcellmemoryformation |