Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis

Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis

Abstract Background Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifestation, positive cerebrospinal fluid (CSF) cytology, and/or neuroimaging...

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Bibliographic Details
Main Authors: Yue Zhao, Jun-Ying He, Yue-Li Zou, Xiao-Su Guo, Jun-Zhao Cui, Li Guo, Hui Bu
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Neurology
Subjects:
Meningeal Carcinomatosis
Cerebrospinal fluid ctDNA
Next-generation sequencing
Cancer-associated gene mutations
Online Access:https://doi.org/10.1186/s12883-019-1554-5

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