The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy
BackgroundPrevious findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after ch...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.942036/full |
| _version_ | 1811265295066595328 |
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| author | Wen Li Yue Lv Xu Duan Guo Cheng Senbang Yao Sheng Yu Lingxue Tang Huaidong Cheng |
| author_facet | Wen Li Yue Lv Xu Duan Guo Cheng Senbang Yao Sheng Yu Lingxue Tang Huaidong Cheng |
| author_sort | Wen Li |
| collection | DOAJ |
| description | BackgroundPrevious findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after chemotherapy were still unknown.ObjectiveThe current study aimed to investigate the potential correlations between pain empathy impairment and event-related potentials (ERP) in breast cancer patients undergoing chemotherapy.MethodsTwenty-two breast cancer patients were evaluated on a neuropsychological test and pain empathy paradigm before and after chemotherapy, containing the Chinese version of the Interpersonal Reactivity Index (IRI-C), while recording ERP data.ResultsThe empathic concern scores were lower and personal distress scores were higher on IRI-C task compared with those before chemotherapy (t = 3.039, p < 0.01; t = −2.324, p < 0.05, respectively). Meanwhile, the accuracy rates were lower than those before chemotherapy for both pain and laterality tasks on the pain empathy paradigm (F = 5.099, P = 0.035). However, the response time was no significant differences before and after chemotherapy (F = 0.543, P = 0.469). Further, the amplitude of the N1 component was significantly increased (F = 38.091, P < 0.001), and the amplitude of the P2 component was significantly decreased (F = 15.046, P = 0.001) in the subsequent ERP study. A linear mixed effect model was used to analyze the correlation, the average amplitude of N1 and P2 were positively correlated with the accuracy rates in laterality tasks (r = 1.765, r = 1.125, respectively, P < 0.05).ConclusionThe results indicated that pain empathy impairment was performed in chemotherapeutic breast cancer patients, which was possibly correlated to the changes of N1 and P2 components in ERP. These findings provide neuro-electrophysiological information about chemo-brain in breast cancer patients. |
| first_indexed | 2024-04-12T20:20:07Z |
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| language | English |
| last_indexed | 2024-04-12T20:20:07Z |
| publishDate | 2022-09-01 |
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| series | Frontiers in Psychology |
| spelling | doaj.art-1491f68b16df49228a95372c955c3e452022-12-22T03:18:00ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-09-011310.3389/fpsyg.2022.942036942036The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapyWen Li0Yue Lv1Xu Duan2Guo Cheng3Senbang Yao4Sheng Yu5Lingxue Tang6Huaidong Cheng7Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Finance, University of Connecticut, Storrs, CT, United StatesDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaBackgroundPrevious findings indicated that breast cancer patients often have dysfunction in empathy and other cognitive functions during or after chemotherapy. However, the manifestations and possible neuro-electrophysiological mechanisms of pain empathy impairment in breast cancer patients after chemotherapy were still unknown.ObjectiveThe current study aimed to investigate the potential correlations between pain empathy impairment and event-related potentials (ERP) in breast cancer patients undergoing chemotherapy.MethodsTwenty-two breast cancer patients were evaluated on a neuropsychological test and pain empathy paradigm before and after chemotherapy, containing the Chinese version of the Interpersonal Reactivity Index (IRI-C), while recording ERP data.ResultsThe empathic concern scores were lower and personal distress scores were higher on IRI-C task compared with those before chemotherapy (t = 3.039, p < 0.01; t = −2.324, p < 0.05, respectively). Meanwhile, the accuracy rates were lower than those before chemotherapy for both pain and laterality tasks on the pain empathy paradigm (F = 5.099, P = 0.035). However, the response time was no significant differences before and after chemotherapy (F = 0.543, P = 0.469). Further, the amplitude of the N1 component was significantly increased (F = 38.091, P < 0.001), and the amplitude of the P2 component was significantly decreased (F = 15.046, P = 0.001) in the subsequent ERP study. A linear mixed effect model was used to analyze the correlation, the average amplitude of N1 and P2 were positively correlated with the accuracy rates in laterality tasks (r = 1.765, r = 1.125, respectively, P < 0.05).ConclusionThe results indicated that pain empathy impairment was performed in chemotherapeutic breast cancer patients, which was possibly correlated to the changes of N1 and P2 components in ERP. These findings provide neuro-electrophysiological information about chemo-brain in breast cancer patients.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.942036/fullbreast cancerpain empathychemotherapyevent-related potentials (ERP)cognitive |
| spellingShingle | Wen Li Yue Lv Xu Duan Guo Cheng Senbang Yao Sheng Yu Lingxue Tang Huaidong Cheng The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy Frontiers in Psychology breast cancer pain empathy chemotherapy event-related potentials (ERP) cognitive |
| title | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| title_full | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| title_fullStr | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| title_full_unstemmed | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| title_short | The alterations in event-related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| title_sort | alterations in event related potential responses to pain empathy in breast cancer survivors treated with chemotherapy |
| topic | breast cancer pain empathy chemotherapy event-related potentials (ERP) cognitive |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.942036/full |
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