Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women
Abstract Background Existing evidence suggest that low concentrations of vitamin A and E may have a contribution to the development of diabetes complications; however, data regarding the status of vitamin A and E among individuals with prediabetes are lacking. This study aimed to examine the associa...
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| Format: | Article |
| Language: | English |
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BMC
2020-02-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13098-020-00525-3 |
| _version_ | 1819080434726731776 |
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| author | Hebah Alawi Kutbi Sahar Ali Hammouda |
| author_facet | Hebah Alawi Kutbi Sahar Ali Hammouda |
| author_sort | Hebah Alawi Kutbi |
| collection | DOAJ |
| description | Abstract Background Existing evidence suggest that low concentrations of vitamin A and E may have a contribution to the development of diabetes complications; however, data regarding the status of vitamin A and E among individuals with prediabetes are lacking. This study aimed to examine the association of plasma concentrations of vitamin A and E with the glycemic control status among first trimester pregnant Saudi women. Methods In this cross-sectional study, 1102 first trimester pregnant Saudi women were recruited from antenatal clinics. Sociodemographic and anthropometric information were collected, and laboratory analyses of blood glycated hemoglobin (A1C) and plasma vitamins A and E were performed. Subjects were classified as normoglycemic, prediabetic, or undiagnosed diabetic. Multinomial regression models adjusted for age estimated the adjusted odds ratios (aORs) and [95% confidence intervals (CIs)]. Results Among the sample, 78.8% (n = 868) had normal glycemic control, while 19.1% (n = 211) had prediabetes and 2.1% (n = 23) had undiagnosed diabetes. Plasma concentrations of vitamin A and E of prediabetic participants were at a level midway between that of normoglycemic and diabetic participants (p < 0.01). Compared to subjects with normoglycemic status, those with higher concentrations of vitamin A and E had lower odds of being prediabetic (aOR = 0.27 [0.21–0.35] and aOR = 0.95 [0.94–0.96], respectively) or diabetic (aOR = 0.18 [0.13–0.24] and aOR = 0.93 [0.92–0.94], respectively). Conclusions Our findings indicate a possible contribution of vitamins A and E to the progression of prediabetes to diabetes. Future longitudinal studies are needed to elucidate the association between the antioxidant status and dysglycemia. Clinicians should monitor the glycemic and the antioxidant status closely and provide dietary guidance where needed. |
| first_indexed | 2024-12-21T19:44:50Z |
| format | Article |
| id | doaj.art-149334c95eec402495a0c4ca3379dd7b |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-12-21T19:44:50Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-149334c95eec402495a0c4ca3379dd7b2022-12-21T18:52:21ZengBMCDiabetology & Metabolic Syndrome1758-59962020-02-011211710.1186/s13098-020-00525-3Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi womenHebah Alawi Kutbi0Sahar Ali Hammouda1Clinical Nutrition Department, Faculty of Applied Medical Sciences, King Abdulaziz UniversityClinical Nutrition Department, College of Applied Medical Sciences, Taibah UniversityAbstract Background Existing evidence suggest that low concentrations of vitamin A and E may have a contribution to the development of diabetes complications; however, data regarding the status of vitamin A and E among individuals with prediabetes are lacking. This study aimed to examine the association of plasma concentrations of vitamin A and E with the glycemic control status among first trimester pregnant Saudi women. Methods In this cross-sectional study, 1102 first trimester pregnant Saudi women were recruited from antenatal clinics. Sociodemographic and anthropometric information were collected, and laboratory analyses of blood glycated hemoglobin (A1C) and plasma vitamins A and E were performed. Subjects were classified as normoglycemic, prediabetic, or undiagnosed diabetic. Multinomial regression models adjusted for age estimated the adjusted odds ratios (aORs) and [95% confidence intervals (CIs)]. Results Among the sample, 78.8% (n = 868) had normal glycemic control, while 19.1% (n = 211) had prediabetes and 2.1% (n = 23) had undiagnosed diabetes. Plasma concentrations of vitamin A and E of prediabetic participants were at a level midway between that of normoglycemic and diabetic participants (p < 0.01). Compared to subjects with normoglycemic status, those with higher concentrations of vitamin A and E had lower odds of being prediabetic (aOR = 0.27 [0.21–0.35] and aOR = 0.95 [0.94–0.96], respectively) or diabetic (aOR = 0.18 [0.13–0.24] and aOR = 0.93 [0.92–0.94], respectively). Conclusions Our findings indicate a possible contribution of vitamins A and E to the progression of prediabetes to diabetes. Future longitudinal studies are needed to elucidate the association between the antioxidant status and dysglycemia. Clinicians should monitor the glycemic and the antioxidant status closely and provide dietary guidance where needed.http://link.springer.com/article/10.1186/s13098-020-00525-3Vitamin AVitamin EAntioxidantGlycemic control |
| spellingShingle | Hebah Alawi Kutbi Sahar Ali Hammouda Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women Diabetology & Metabolic Syndrome Vitamin A Vitamin E Antioxidant Glycemic control |
| title | Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women |
| title_full | Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women |
| title_fullStr | Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women |
| title_full_unstemmed | Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women |
| title_short | Plasma concentrations of vitamin A and E and risk of dysglycemia in first-trimester pregnant Saudi women |
| title_sort | plasma concentrations of vitamin a and e and risk of dysglycemia in first trimester pregnant saudi women |
| topic | Vitamin A Vitamin E Antioxidant Glycemic control |
| url | http://link.springer.com/article/10.1186/s13098-020-00525-3 |
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