Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage
Aim. Investigation of the extent of morphological changes and activity of biogenic amines (according to the intensity of luminescence) in the neurons of the brain stem in intracerebral hemorrhage (ICH). Methods and results. ICH was designed on 29 white rats of Vistar line by the administration...
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| Format: | Article |
| Language: | English |
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Zaporozhye State Medical University
2015-10-01
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| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/53717/50321 |
| _version_ | 1819093002169090048 |
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| author | S. I. Tertishniy |
| author_facet | S. I. Tertishniy |
| author_sort | S. I. Tertishniy |
| collection | DOAJ |
| description | Aim. Investigation of the extent of morphological changes and activity of biogenic amines (according to the intensity of luminescence) in the neurons of the brain stem in intracerebral hemorrhage (ICH).
Methods and results. ICH was designed on 29 white rats of Vistar line by the administration of autologous blood in the cerebral hemisphere. It was revealed that increased luminescence intensity by 18.4±5.5% was registered in monoaminergic neurons in 1–6 hours after experimental ICH. After 12 hours – 1 day development of dislocation syndrome leads to mosaic focal ischemic neuronal injuries with maximum reduction in the level of catecholamines by 29.5±5.0% compared with control cases. Three–6 days after ICH on a background of selective neuronal necrosis in substantial number of neurons in the nuclei of the brainstem the level of catecholamines is significantly reduced.
Conclusion. Disclosed observations reflect significant functional pathology of neurons responsible for the regulation of cardiorespiratory function and may underlie disturbances of integrative activity in the brain stem in general. |
| first_indexed | 2024-12-21T23:04:35Z |
| format | Article |
| id | doaj.art-14955c1635d64b1aabd9b01db52751a2 |
| institution | Directory Open Access Journal |
| issn | 2306-4145 2310-1210 |
| language | English |
| last_indexed | 2024-12-21T23:04:35Z |
| publishDate | 2015-10-01 |
| publisher | Zaporozhye State Medical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj.art-14955c1635d64b1aabd9b01db52751a22022-12-21T18:47:12ZengZaporozhye State Medical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102015-10-0156265http://dx.doi.org/10.14739/2310-1210.2015.5.53717Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhageS. I. TertishniyAim. Investigation of the extent of morphological changes and activity of biogenic amines (according to the intensity of luminescence) in the neurons of the brain stem in intracerebral hemorrhage (ICH). Methods and results. ICH was designed on 29 white rats of Vistar line by the administration of autologous blood in the cerebral hemisphere. It was revealed that increased luminescence intensity by 18.4±5.5% was registered in monoaminergic neurons in 1–6 hours after experimental ICH. After 12 hours – 1 day development of dislocation syndrome leads to mosaic focal ischemic neuronal injuries with maximum reduction in the level of catecholamines by 29.5±5.0% compared with control cases. Three–6 days after ICH on a background of selective neuronal necrosis in substantial number of neurons in the nuclei of the brainstem the level of catecholamines is significantly reduced. Conclusion. Disclosed observations reflect significant functional pathology of neurons responsible for the regulation of cardiorespiratory function and may underlie disturbances of integrative activity in the brain stem in general.http://zmj.zsmu.edu.ua/article/view/53717/50321Experimentation AnimalBrainstemMonoaminergic NeuronsHistochemistryCerebral Hemorrhage |
| spellingShingle | S. I. Tertishniy Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage Zaporožskij Medicinskij Žurnal Experimentation Animal Brainstem Monoaminergic Neurons Histochemistry Cerebral Hemorrhage |
| title | Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| title_full | Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| title_fullStr | Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| title_full_unstemmed | Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| title_short | Morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| title_sort | morphological and histochemical changes in the brain stem in case of experimental hemispheric intracerebral hemorrhage |
| topic | Experimentation Animal Brainstem Monoaminergic Neurons Histochemistry Cerebral Hemorrhage |
| url | http://zmj.zsmu.edu.ua/article/view/53717/50321 |
| work_keys_str_mv | AT sitertishniy morphologicalandhistochemicalchangesinthebrainstemincaseofexperimentalhemisphericintracerebralhemorrhage |