Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults
Purpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.Materials and methods: We conducted a cross-sec...
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| Format: | Article |
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Frontiers Media S.A.
2020-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2020.594786/full |
| _version_ | 1818602674749177856 |
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| author | Jing Wang Jing Wang Jing Wang Jing Wang Anxin Wang Anxin Wang Anxin Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_facet | Jing Wang Jing Wang Jing Wang Jing Wang Anxin Wang Anxin Wang Anxin Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao |
| author_sort | Jing Wang |
| collection | DOAJ |
| description | Purpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.Materials and methods: We conducted a cross-sectional analysis of the follow-up data of 2012 from the APAC study. The Chinese version of the MMSE was used as a cognitive screener, and an MMSE score <24 is generally accepted as indicating cognitive impairment. Multivariable logistic regression was used to estimate the interactions of hs-CRP levels with body mass index (BMI) on the effects of cognitive impairment and its subtypes.Results: Three thousand eight hundred seventy-five participants aged 40–90 years (median age 51.64 y) were enrolled in this study, and 1,788 (46.1%) were overweight. Before and after adjusting for confounders, such as age, sex, BMI, education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hs-CRP, elevated hs-CRP levels were associated with cognitive impairment in normal-weight participants (crude OR: 2.08, 95%CI: 1.28–3.37, p = 0.003; adjusted OR: 2.06, 95%CI: 1.03–4.10, p = 0.04), but not in overweight participants. There was no statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-item.Conclusion: Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants. |
| first_indexed | 2024-12-16T13:11:02Z |
| format | Article |
| id | doaj.art-14956fdb86d24c059b5f31a4d401da01 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-16T13:11:02Z |
| publishDate | 2020-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-14956fdb86d24c059b5f31a4d401da012022-12-21T22:30:36ZengFrontiers Media S.A.Frontiers in Neurology1664-22952020-12-011110.3389/fneur.2020.594786594786Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese AdultsJing Wang0Jing Wang1Jing Wang2Jing Wang3Anxin Wang4Anxin Wang5Anxin Wang6Xingquan Zhao7Xingquan Zhao8Xingquan Zhao9Xingquan Zhao10Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, ChinaDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaChina National Clinical Research Center for Neurological Diseases, Beijing, ChinaCenter of Stroke, Beijing Institute for Brain Disorders, Beijing, ChinaBeijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, ChinaPurpose: To determine the association between overweight and high-sensitivity C-reactive protein (hs-CRP) with the odds of cognitive impairment as well as its subtypes based on the Asymptomatic Polyvascular Abnormalities Community (APAC) study in China.Materials and methods: We conducted a cross-sectional analysis of the follow-up data of 2012 from the APAC study. The Chinese version of the MMSE was used as a cognitive screener, and an MMSE score <24 is generally accepted as indicating cognitive impairment. Multivariable logistic regression was used to estimate the interactions of hs-CRP levels with body mass index (BMI) on the effects of cognitive impairment and its subtypes.Results: Three thousand eight hundred seventy-five participants aged 40–90 years (median age 51.64 y) were enrolled in this study, and 1,788 (46.1%) were overweight. Before and after adjusting for confounders, such as age, sex, BMI, education, current smoking, drinking, physical activity, hypertension, hyperlipidemia, diabetes, and hs-CRP, elevated hs-CRP levels were associated with cognitive impairment in normal-weight participants (crude OR: 2.08, 95%CI: 1.28–3.37, p = 0.003; adjusted OR: 2.06, 95%CI: 1.03–4.10, p = 0.04), but not in overweight participants. There was no statistically significant evidence for the interaction between hs-CRP and BMI on any cognitive sub-item.Conclusion: Elevated hs-CRP levels increase the odds of cognitive impairment in normal-weight participants, but not in overweight participants.https://www.frontiersin.org/articles/10.3389/fneur.2020.594786/fullhigh-sensitivity C-reactive protein (hs-CRP)cognitive impairmentoverweightbody mass indexinflammation |
| spellingShingle | Jing Wang Jing Wang Jing Wang Jing Wang Anxin Wang Anxin Wang Anxin Wang Xingquan Zhao Xingquan Zhao Xingquan Zhao Xingquan Zhao Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults Frontiers in Neurology high-sensitivity C-reactive protein (hs-CRP) cognitive impairment overweight body mass index inflammation |
| title | Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults |
| title_full | Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults |
| title_fullStr | Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults |
| title_full_unstemmed | Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults |
| title_short | Relationship Among Inflammation, Overweight Status, and Cognitive Impairment in a Community-Based Population of Chinese Adults |
| title_sort | relationship among inflammation overweight status and cognitive impairment in a community based population of chinese adults |
| topic | high-sensitivity C-reactive protein (hs-CRP) cognitive impairment overweight body mass index inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2020.594786/full |
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