Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis

Kefir peptides ameliorate osteoporosis in AKR1A1 knockout mice with vitamin C deficiency by promoting osteoblastogenesis and inhibiting osteoclastogenesis

The AKR1A1 protein is a member of the aldo-keto reductase superfamily that catalyzes the transformation of D-glucuronate to L-gulonate in the synthesis of L-ascorbic acid (vitamin C, Vit C). We previously demonstrated that AKR1A1 knockout mice (AKR1A1eGFP/eGFP) with Vit C deficiency exhibited aberra...

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Bibliographic Details
Main Authors: Gary Ro-Lin Chang, Wei-Yu Lin, Hueng-Chuen Fan, Min-Yu Tu, Yu-Hsien Liu, Chih-Ching Yen, Abdulkadir Cidem, Wei Chen, Chuan-Mu Chen
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
AKR1A1
Vitamin C (Vit C)
Osteoporosis
Kefir peptides (KPs)
Osteoblastogenesis
Osteoclastogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222012483

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http://www.sciencedirect.com/science/article/pii/S0753332222012483

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