Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R

Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R

Abstract Overfeeding triggers homeostatic compensatory mechanisms that counteract weight gain. Here, we show that both lean and diet-induced obese (DIO) male mice exhibit a potent and prolonged inhibition of voluntary food intake following overfeeding-induced weight gain. We reveal that FGF21 is dis...

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Bibliographic Details
Main Authors: Camilla Lund, Pablo Ranea-Robles, Sarah Falk, Dylan M. Rausch, Grethe Skovbjerg, Victoria Kamma Vibe-Petersen, Nathalie Krauth, Jacob Lercke Skytte, Vasiliki Vana, Urmas Roostalu, Tune H. Pers, Jens Lund, Christoffer Clemmensen
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-45223-0

Internet

https://doi.org/10.1038/s41467-024-45223-0

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