The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis
Background: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic effects, including anti-inflammatory properties. Atherosclerosis is a low-grade...
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5251 |
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| author | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Manfredi Rizzo Ali H. Eid Amirhossein Sahebkar |
| author_facet | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Manfredi Rizzo Ali H. Eid Amirhossein Sahebkar |
| author_sort | Tannaz Jamialahmadi |
| collection | DOAJ |
| description | Background: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic effects, including anti-inflammatory properties. Atherosclerosis is a low-grade inflammatory disease, and elevated ferritin is considered to be one of the markers of inflammation. Since the results of studies on the effects of statins on serum ferritin levels are conflicting, this meta-analysis was performed. Methods: A literature search was performed using major electronic databases (MEDLINE/PubMed, Scopus, Embase, and ISI Web of Science) from inception up to 5 March 2022 to find studies evaluating the effect of different statins on serum ferritin levels. The effect size was determined using weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Results: The meta-analysis of nine studies (1611 patients) analyzing the effects of statins on serum ferritin levels that were included showed a significant decrease in circulating ferritin levels caused by statins. The results did not suggest any significant association between the changes in concentrations of serum ferritin and the duration of treatment with statins. Conclusions: Statin therapy decreases the circulating concentrations of ferritin, which might be beneficial for the prevention and/or progression of ASCVD. This effect might be explained by the anti-inflammatory effects and maybe some other pleiotropic effects of statins and not by their lipid-lowering effects. |
| first_indexed | 2024-03-10T01:37:08Z |
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| id | doaj.art-149c8f20a2bb4e669c30e3d046e131f5 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:37:08Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-149c8f20a2bb4e669c30e3d046e131f52023-11-23T13:30:21ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011117525110.3390/jcm11175251The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-AnalysisTannaz Jamialahmadi0Mitra Abbasifard1Željko Reiner2Manfredi Rizzo3Ali H. Eid4Amirhossein Sahebkar5Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad 9177948564, IranImmunology of Infectious Diseases Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan 7717933777, IranDepartment of Internal Medicine, University Hospital Center Zagreb, 10000 Zagreb, CroatiaDepartment of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, School of Medicine, University of Palermo, 90133 Palermo, ItalyDepartment of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha P.O. Box 2713, QatarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948954, IranBackground: Statins are the most widely used drugs for decreasing elevated serum LDL-cholesterol (LDL-C) and thus for the prevention of atherosclerotic cardiovascular disease (ASCVD), but they have also some pleiotropic effects, including anti-inflammatory properties. Atherosclerosis is a low-grade inflammatory disease, and elevated ferritin is considered to be one of the markers of inflammation. Since the results of studies on the effects of statins on serum ferritin levels are conflicting, this meta-analysis was performed. Methods: A literature search was performed using major electronic databases (MEDLINE/PubMed, Scopus, Embase, and ISI Web of Science) from inception up to 5 March 2022 to find studies evaluating the effect of different statins on serum ferritin levels. The effect size was determined using weighted mean differences (WMDs) and the corresponding 95% confidence intervals (CIs). Results: The meta-analysis of nine studies (1611 patients) analyzing the effects of statins on serum ferritin levels that were included showed a significant decrease in circulating ferritin levels caused by statins. The results did not suggest any significant association between the changes in concentrations of serum ferritin and the duration of treatment with statins. Conclusions: Statin therapy decreases the circulating concentrations of ferritin, which might be beneficial for the prevention and/or progression of ASCVD. This effect might be explained by the anti-inflammatory effects and maybe some other pleiotropic effects of statins and not by their lipid-lowering effects.https://www.mdpi.com/2077-0383/11/17/5251acute-phase responselipid-lowering therapyinflammationironstatinscardiovascular diseases |
| spellingShingle | Tannaz Jamialahmadi Mitra Abbasifard Željko Reiner Manfredi Rizzo Ali H. Eid Amirhossein Sahebkar The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis Journal of Clinical Medicine acute-phase response lipid-lowering therapy inflammation iron statins cardiovascular diseases |
| title | The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis |
| title_full | The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis |
| title_fullStr | The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis |
| title_short | The Effects of Statin Treatment on Serum Ferritin Levels: A Systematic Review and Meta-Analysis |
| title_sort | effects of statin treatment on serum ferritin levels a systematic review and meta analysis |
| topic | acute-phase response lipid-lowering therapy inflammation iron statins cardiovascular diseases |
| url | https://www.mdpi.com/2077-0383/11/17/5251 |
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