Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions
Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can be classified into animal- and plant-derived ω-3 PUFAs. Patients with type 2 diabetes (T2DM) are frequently accompanied by dyslipidemia, which is closely related to the high-density lipoprotein (HDL-C) subfractions change. This study aimed...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2023-11-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000940 |
| _version_ | 1797697940565786624 |
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| author | Hechun Liu Feng Wang Hui Xia Da Pan Ligang Yang Shaokang Wang Feng Zhao Guiju Sun |
| author_facet | Hechun Liu Feng Wang Hui Xia Da Pan Ligang Yang Shaokang Wang Feng Zhao Guiju Sun |
| author_sort | Hechun Liu |
| collection | DOAJ |
| description | Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can be classified into animal- and plant-derived ω-3 PUFAs. Patients with type 2 diabetes (T2DM) are frequently accompanied by dyslipidemia, which is closely related to the high-density lipoprotein (HDL-C) subfractions change. This study aimed to determine the effects of different sources ω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with dyslipidemia. Ninety T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fish oil (FO, containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), 3 g/day perilla oil (PO, containing α-linolenic acid (ALA)), or 3 g/day blend oil (BO, containing EPA, DHA and ALA) for 3 months. 90 patients completed the intervention. There was a significant reduction of glycated hemoglobin (HbA1c) in all the groups. The triglycerides (TG) in the FO group were significantly different with a group × time interaction (P = 0.043), which was higher compared with the other two groups. The serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO groups. Plant-derived ω-3 PUFAs are more effective at controlling blood glucose than animal-derived ω-3 PUFAs. However, animal-derived ω-3 PUFAs have a significant lowering effect on TG compared with plant-derived ω-3 PUFAs. Particularly, large HDL-C subfractions after animal-derived ω-3 PUFAs intake were higher than plant-derived ω-3 PUFAs intake; while small HDL-C subfractions were lower. Both the animal- and plant-derived ω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia. |
| first_indexed | 2024-03-12T03:47:09Z |
| format | Article |
| id | doaj.art-149d577f0e6e49d3a6c8688cedf21f73 |
| institution | Directory Open Access Journal |
| issn | 2213-4530 |
| language | English |
| last_indexed | 2024-03-12T03:47:09Z |
| publishDate | 2023-11-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj.art-149d577f0e6e49d3a6c8688cedf21f732023-09-03T12:36:26ZengTsinghua University PressFood Science and Human Wellness2213-45302023-11-0112622212231Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractionsHechun Liu0Feng Wang1Hui Xia2Da Pan3Ligang Yang4Shaokang Wang5Feng Zhao6Guiju Sun7Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China; Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China; Tianjin Institute of Environmental and Operational Medicine, Tianjin 300050, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, ChinaResearch Center of Fatty Acid and Human Health, Qingdao University, Qingdao 266000, ChinaKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China; Corresponding author at: Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, No 87 Ding Jia Qiao Road, Nanjing 210009, China.Dietary omega-3 polyunsaturated fatty acids (ω-3 PUFAs) can be classified into animal- and plant-derived ω-3 PUFAs. Patients with type 2 diabetes (T2DM) are frequently accompanied by dyslipidemia, which is closely related to the high-density lipoprotein (HDL-C) subfractions change. This study aimed to determine the effects of different sources ω-3 PUFAs on glucolipid metabolism and lipoprotein subfractions in T2DM with dyslipidemia. Ninety T2DM patients with dyslipidemia were randomly assigned to take 3 g/day fish oil (FO, containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), 3 g/day perilla oil (PO, containing α-linolenic acid (ALA)), or 3 g/day blend oil (BO, containing EPA, DHA and ALA) for 3 months. 90 patients completed the intervention. There was a significant reduction of glycated hemoglobin (HbA1c) in all the groups. The triglycerides (TG) in the FO group were significantly different with a group × time interaction (P = 0.043), which was higher compared with the other two groups. The serum small HDL-C subfractions in the PO group was higher and the serum large HDL-C subfractions in the PO group was lower than those in the BO and FO groups. Plant-derived ω-3 PUFAs are more effective at controlling blood glucose than animal-derived ω-3 PUFAs. However, animal-derived ω-3 PUFAs have a significant lowering effect on TG compared with plant-derived ω-3 PUFAs. Particularly, large HDL-C subfractions after animal-derived ω-3 PUFAs intake were higher than plant-derived ω-3 PUFAs intake; while small HDL-C subfractions were lower. Both the animal- and plant-derived ω-3 PUFAs have practical value in improving glucose and lipids metabolism in T2DM patients with dyslipidemia.http://www.sciencedirect.com/science/article/pii/S2213453023000940DiabetesOmega-3 polyunsaturated fatty acidLipoprotein subfractionDyslipidemia |
| spellingShingle | Hechun Liu Feng Wang Hui Xia Da Pan Ligang Yang Shaokang Wang Feng Zhao Guiju Sun Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions Food Science and Human Wellness Diabetes Omega-3 polyunsaturated fatty acid Lipoprotein subfraction Dyslipidemia |
| title | Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| title_full | Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| title_fullStr | Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| title_full_unstemmed | Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| title_short | Comparison of the effects of 3 kinds of oils rich in omega-3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| title_sort | comparison of the effects of 3 kinds of oils rich in omega 3 polyunsaturated fatty acids on glycolipid metabolism and lipoprotein subfractions |
| topic | Diabetes Omega-3 polyunsaturated fatty acid Lipoprotein subfraction Dyslipidemia |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000940 |
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