Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery
Background Reducing postoperative pain can improve patient satisfaction and hospital cost. Intravenous magnesium sulfate is one of the proposed drugs for preemptive analgesia. The study aimed to evaluate the effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surge...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine Trisakti University
2019-10-01
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| Series: | Universa Medicina |
| Subjects: | |
| Online Access: | https://univmed.org/ejurnal/index.php/medicina/article/view/726 |
| _version_ | 1818596166623821824 |
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| author | Abasali Delavari Marzieh Lak Hassan Arragizade Babak Salatini |
| author_facet | Abasali Delavari Marzieh Lak Hassan Arragizade Babak Salatini |
| author_sort | Abasali Delavari |
| collection | DOAJ |
| description | Background
Reducing postoperative pain can improve patient satisfaction and hospital cost. Intravenous magnesium sulfate is one of the proposed drugs for preemptive analgesia. The study aimed to evaluate the effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery.
Methods
A double-blind randomized clinical trial was conducted on candidates for vertebral fusion surgery with American Society of Anesthesiologists (ASA) class I-II. One hundred and two patients were randomized into the magnesium sulfate group and control group. The magnesium sulfate group received magnesium sulfate at a dose of 50mg/kg in 20 mL volume and infused during 15-30 minutes pre-operation, while the control group received 20 mL normal saline. The severity of the pain was assessed by the Visual Analogue Scale (VAS) at 2, 4, 6, 12 and 24 hours after patients entering the post-anesthetic care unit. After the operation, the patients’ relaxation rate was assessed based on Ramsay sedation score (RSS).
Results
There was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean severity of pain (p>0.05). There was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean of pethidine consumption. There was no significant difference in the relaxation of the patients according to the RSS criteria in the magnesium sulfate and control groups (p=0.162).
Conclusion
Pre-operative administration of magnesium sulfate does not affect reduction in postoperative pain and opioid consumption of patients undergoing lumbar fusion surgery. |
| first_indexed | 2024-12-16T11:27:36Z |
| format | Article |
| id | doaj.art-14a5c790c9284226811f0558d10e194c |
| institution | Directory Open Access Journal |
| issn | 1907-3062 2407-2230 |
| language | English |
| last_indexed | 2024-12-16T11:27:36Z |
| publishDate | 2019-10-01 |
| publisher | Faculty of Medicine Trisakti University |
| record_format | Article |
| series | Universa Medicina |
| spelling | doaj.art-14a5c790c9284226811f0558d10e194c2022-12-21T22:33:18ZengFaculty of Medicine Trisakti UniversityUniversa Medicina1907-30622407-22302019-10-0138310.18051/UnivMed.2019.v38.156-163385Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgeryAbasali Delavari0Marzieh Lak1Hassan Arragizade2Babak Salatini3Trauma Research Center, Baqiyatallah University of Medical Sciences, TehranTrauma Research Center, Baqiyatallah University of Medical Sciences, TehranTrauma Research Center, Baqiyatallah University of Medical Sciences, TehranTrauma Research Center, Baqiyatallah University of Medical Sciences, TehranBackground Reducing postoperative pain can improve patient satisfaction and hospital cost. Intravenous magnesium sulfate is one of the proposed drugs for preemptive analgesia. The study aimed to evaluate the effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery. Methods A double-blind randomized clinical trial was conducted on candidates for vertebral fusion surgery with American Society of Anesthesiologists (ASA) class I-II. One hundred and two patients were randomized into the magnesium sulfate group and control group. The magnesium sulfate group received magnesium sulfate at a dose of 50mg/kg in 20 mL volume and infused during 15-30 minutes pre-operation, while the control group received 20 mL normal saline. The severity of the pain was assessed by the Visual Analogue Scale (VAS) at 2, 4, 6, 12 and 24 hours after patients entering the post-anesthetic care unit. After the operation, the patients’ relaxation rate was assessed based on Ramsay sedation score (RSS). Results There was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean severity of pain (p>0.05). There was no significant difference at 2, 4, 6, 12 and 24 hours post-operation between the two groups in the mean of pethidine consumption. There was no significant difference in the relaxation of the patients according to the RSS criteria in the magnesium sulfate and control groups (p=0.162). Conclusion Pre-operative administration of magnesium sulfate does not affect reduction in postoperative pain and opioid consumption of patients undergoing lumbar fusion surgery.https://univmed.org/ejurnal/index.php/medicina/article/view/726Painmagnesium sulfatevertebral fusion surgery |
| spellingShingle | Abasali Delavari Marzieh Lak Hassan Arragizade Babak Salatini Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery Universa Medicina Pain magnesium sulfate vertebral fusion surgery |
| title | Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| title_full | Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| title_fullStr | Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| title_full_unstemmed | Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| title_short | Preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| title_sort | preemptive analgesic effect of magnesium sulfate on postoperative pain in patients undergoing lumbar fusion surgery |
| topic | Pain magnesium sulfate vertebral fusion surgery |
| url | https://univmed.org/ejurnal/index.php/medicina/article/view/726 |
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