Susceptibility of Ovine Bone Marrow-Derived Mesenchymal Stem Cell Spheroids to Scrapie Prion Infection

Susceptibility of Ovine Bone Marrow-Derived Mesenchymal Stem Cell Spheroids to Scrapie Prion Infection

In neurodegenerative diseases, including prion diseases, cellular in vitro models appear as fundamental tools for the study of pathogenic mechanisms and potential therapeutic compounds. Two-dimensional (2D) monolayer cell culture systems are the most used cell-based assays, but these platforms are n...

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Bibliographic Details
Main Authors: Adelaida Hernaiz, Paula Cobeta, Belén Marín, Francisco José Vázquez, Juan José Badiola, Pilar Zaragoza, Rosa Bolea, Inmaculada Martín-Burriel
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Animals
Subjects:
3D culture
spheroids
mesenchymal stem cells
scrapie
prion
Online Access:https://www.mdpi.com/2076-2615/13/6/1043

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