DRUGS DEVELOPED AT «ARC BASS» WITH M.D. MASHKOVSKII LEAD (REVIEW)
Introduction. There are presented data on drugs development with M.D. Mashkovskii lead. There are given materials on drugs belonging to important pharmacotherapeutic groups of drugs such as generic and original drugs. Original syntheses of famous generic drugs and improved industrial technologies ha...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-02-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/642 |
| Summary: | Introduction. There are presented data on drugs development with M.D. Mashkovskii lead. There are given materials on drugs belonging to important pharmacotherapeutic groups of drugs such as generic and original drugs. Original syntheses of famous generic drugs and improved industrial technologies have been developed. The attention is paid to high quality of produced drugs. More than 200 new molecules were synthesized while developing original structures of nitrobenzamide derivatives. The studies of pharmacological and toxicological characteristics have helped to choose and create original antiarrhythmic nibentan and niferidyl. The drugs are registered in the Ministry of Healthcare of the Russian Federation and included in essential drugs list.Text. VNIKHFI branch called today VNC BAV founded in 1966. M.D. Mashkovskii offered that creation to expand scientific and experimental base of drugs development. It continues to research and develop new drugs including syntheses of original molecules, developing of industrial technology, and preclinical research of pharmacological activities, drug safety, and toxicology. Original synthesis schemes are described shortly in the article. Industrial technologies of pharmacopoeial substance synthesis are developed out of these schemes such as γ-butyric acid, dopamine, analgin for injection, and original drugs nibentan – ((RS) N-[5-(diethylamino)-1-phenylpentyl]-4-nitrobenzamide hydrochloride), niferidyl – N-1-[(4-fluorophenyl)- 2-(1-ethyl-4-piperidyl)ethyl]-4-nitrobenzamide hydrochloride. The release of developed drugs to the national industrial production is specially noted.Conclusion. M.D. Mashkovskii always supported national drugs development by submitting valuable offers, paying constant attention to scientific research, quality of drugs, and drugs production in industrial quantities for securing national healthcare with national drugs. |
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| ISSN: | 2305-2066 2658-5049 |