Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision
Summary: Why some of us remember events more clearly than others and why memory loses precision over time is a major focus in memory research. Here, we show that the recruitment of specific neuroanatomical pathways within the medial temporal lobe (MTL) of the brain defines the precision of the memor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723013293 |
| _version_ | 1797448099383214080 |
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| author | Erika Atucha Shih-Pi Ku Michael T. Lippert Magdalena M. Sauvage |
| author_facet | Erika Atucha Shih-Pi Ku Michael T. Lippert Magdalena M. Sauvage |
| author_sort | Erika Atucha |
| collection | DOAJ |
| description | Summary: Why some of us remember events more clearly than others and why memory loses precision over time is a major focus in memory research. Here, we show that the recruitment of specific neuroanatomical pathways within the medial temporal lobe (MTL) of the brain defines the precision of the memory recalled over the lifespan. Using optogenetics, neuronal activity mapping, and studying recent to very remote memories, we report that the hippocampal subfield CA1 is necessary for retrieving the gist of events and receives maximal support from MTL cortical areas (MEC, LEC, PER, and POR) for recalling the most remote memories. In contrast, reduction of CA3’s activity alone coincides with the loss of memory precision over time. We propose that a shift between specific MTL subnetworks over time might be a fundamental mechanism of memory consolidation. |
| first_indexed | 2024-03-09T14:05:28Z |
| format | Article |
| id | doaj.art-14a8fb6445e64ec18e5f36b6e0d205b5 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-09T14:05:28Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-14a8fb6445e64ec18e5f36b6e0d205b52023-11-30T05:06:44ZengElsevierCell Reports2211-12472023-11-014211113317Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precisionErika Atucha0Shih-Pi Ku1Michael T. Lippert2Magdalena M. Sauvage3Functional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, Germany; Corresponding authorFunctional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, GermanySystems Physiology of Learning Department, Leibniz Institute for Neurobiology, Magdeburg, GermanyFunctional Architecture of Memory Department, Leibniz Institute for Neurobiology, Magdeburg, Germany; Otto von Guericke University, Medical Faculty, Functional Neuroplasticity Department, Magdeburg, Germany; Otto von Guericke University, Center for Behavioral Brain Sciences, Magdeburg, Germany; Corresponding authorSummary: Why some of us remember events more clearly than others and why memory loses precision over time is a major focus in memory research. Here, we show that the recruitment of specific neuroanatomical pathways within the medial temporal lobe (MTL) of the brain defines the precision of the memory recalled over the lifespan. Using optogenetics, neuronal activity mapping, and studying recent to very remote memories, we report that the hippocampal subfield CA1 is necessary for retrieving the gist of events and receives maximal support from MTL cortical areas (MEC, LEC, PER, and POR) for recalling the most remote memories. In contrast, reduction of CA3’s activity alone coincides with the loss of memory precision over time. We propose that a shift between specific MTL subnetworks over time might be a fundamental mechanism of memory consolidation.http://www.sciencedirect.com/science/article/pii/S2211124723013293CP: NeuroscienceCP: Cell biology |
| spellingShingle | Erika Atucha Shih-Pi Ku Michael T. Lippert Magdalena M. Sauvage Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision Cell Reports CP: Neuroscience CP: Cell biology |
| title | Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision |
| title_full | Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision |
| title_fullStr | Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision |
| title_full_unstemmed | Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision |
| title_short | Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision |
| title_sort | recalling gist memory depends on ca1 hippocampal neurons for lifetime retention and ca3 neurons for memory precision |
| topic | CP: Neuroscience CP: Cell biology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723013293 |
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