Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives
This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydraz...
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| Format: | Article |
| Language: | Arabic |
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College of Science for Women, University of Baghdad
2019-09-01
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| Series: | Baghdad Science Journal |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3942 |
| _version_ | 1818231907579592704 |
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| author | Nuaman Alheety |
| author_facet | Nuaman Alheety |
| author_sort | Nuaman Alheety |
| collection | DOAJ |
| description | This research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compound (N1) was treated with formaldehyde, it afforded the compound (N8). Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide. The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (1H-NMR). Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug. |
| first_indexed | 2024-12-12T10:57:51Z |
| format | Article |
| id | doaj.art-14aa21228f1f4ec599c66673623a58a9 |
| institution | Directory Open Access Journal |
| issn | 2078-8665 2411-7986 |
| language | Arabic |
| last_indexed | 2024-12-12T10:57:51Z |
| publishDate | 2019-09-01 |
| publisher | College of Science for Women, University of Baghdad |
| record_format | Article |
| series | Baghdad Science Journal |
| spelling | doaj.art-14aa21228f1f4ec599c66673623a58a92022-12-22T00:26:37ZaraCollege of Science for Women, University of BaghdadBaghdad Science Journal2078-86652411-79862019-09-0116310.21123/bsj.16.3.616Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole DerivativesNuaman AlheetyThis research included the preparation of 2-mercaptobenzoxazole (N1) by the reaction of ortho-aminophenol with carbon disulfide in an alcoholic potassium hydroxide solution. The 2-mercapto benzoxazole (N1) was then treated with hydrazine to obtain the 2-hydrazino benzoxazole (N2). A number of hydrazones (N3-N5) were prepared through the reaction of N2 with different benzaldehydes. The compound (N6) was also prepared whereby the ring closing of hydrazone (N3) using chloroacetylchloride, while the compound (N7) was prepared by treating 2-hydrazino benzoxazole with acetylacetone. When the compound (N1) was treated with formaldehyde, it afforded the compound (N8). Also, the N9 was obtained from the reaction of N1 with chloroacetic acid in the presence of alcoholic potassium hydroxide. The prepared compounds were characterized using physico-chemical and spectroscopic methods such as melting point, infrared spectroscopy (IR) and the proton nuclear magnetic resonance (1H-NMR). Thereafter, some of the compounds were selected for in vitro antibacterial activity and one of these compounds showed an inhibition effect against gram positive only which is very important because it is considered as specific antibacterial drug.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3942Antibacterial activity, Benzoxazole, Gram positive, 2-Mercaptobenzoxazole, Specific antibacterial drug. |
| spellingShingle | Nuaman Alheety Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives Baghdad Science Journal Antibacterial activity, Benzoxazole, Gram positive, 2-Mercaptobenzoxazole, Specific antibacterial drug. |
| title | Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives |
| title_full | Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives |
| title_fullStr | Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives |
| title_full_unstemmed | Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives |
| title_short | Synthesis, Characterization and Antimicrobial Activity Study of Some New Substituted Benzoxazole Derivatives |
| title_sort | synthesis characterization and antimicrobial activity study of some new substituted benzoxazole derivatives |
| topic | Antibacterial activity, Benzoxazole, Gram positive, 2-Mercaptobenzoxazole, Specific antibacterial drug. |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/3942 |
| work_keys_str_mv | AT nuamanalheety synthesischaracterizationandantimicrobialactivitystudyofsomenewsubstitutedbenzoxazolederivatives |