The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task
Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potential. Recent evidence has produced equivocal eviden...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/6/404 |
| _version_ | 1797564125398695936 |
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| author | Claire V. Warren María J. Maraver Alberto de Luca Bruno Kopp |
| author_facet | Claire V. Warren María J. Maraver Alberto de Luca Bruno Kopp |
| author_sort | Claire V. Warren |
| collection | DOAJ |
| description | Transcutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potential. Recent evidence has produced equivocal evidence whether taVNS influences the P3 in healthy individuals during oddball tasks. We examined the effect of taVNS on P3 amplitudes using a novel visual Bayesian oddball task, which presented 200 sequences of three stimuli. The three consecutive stimuli in each sequence are labelled Draw 1, Draw 2 and Draw 3. In total, 47 Subjects completed this visual Bayesian oddball task under randomised sham and active taVNS stimulation in parallel with an electroencephalographic (EEG) recording. We conducted exploratory analyses of the effect of taVNS on P3 amplitudes separately for Draws. We found typical oddball effects on P3 amplitudes at Draws 1 and 2, but not Draw 3. At Draw 2, the oddball effect was enhanced during active compared to sham taVNS stimulation. These data provide evidence that taVNS influences parietal P3 amplitudes under specific circumstances. Only P3 amplitudes at Draw 2 were affected, which may relate to closure of Bayesian inference after Draw 2. Our findings seemingly support previously reported links between taVNS and the NE system. |
| first_indexed | 2024-03-10T18:52:59Z |
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| id | doaj.art-14ab9270910347a1868c45aeabb2eb2c |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T18:52:59Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-14ab9270910347a1868c45aeabb2eb2c2023-11-20T04:58:52ZengMDPI AGBrain Sciences2076-34252020-06-0110640410.3390/brainsci10060404The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball TaskClaire V. Warren0María J. Maraver1Alberto de Luca2Bruno Kopp3Clinic of Neurology, Hannover Medical School, 30519 Hannover, GermanyInstitute of Psychology, Leiden University, 2333 Leiden, The NetherlandsInstitute of Psychology, Leiden University, 2333 Leiden, The NetherlandsClinic of Neurology, Hannover Medical School, 30519 Hannover, GermanyTranscutaneous auricular Vagal Nerve Stimulation (taVNS) is a non-invasive brain stimulation technique associated with possible modulation of norepinephrinergic (NE) activity. NE is suspected to contribute to generation of the P3 event-related potential. Recent evidence has produced equivocal evidence whether taVNS influences the P3 in healthy individuals during oddball tasks. We examined the effect of taVNS on P3 amplitudes using a novel visual Bayesian oddball task, which presented 200 sequences of three stimuli. The three consecutive stimuli in each sequence are labelled Draw 1, Draw 2 and Draw 3. In total, 47 Subjects completed this visual Bayesian oddball task under randomised sham and active taVNS stimulation in parallel with an electroencephalographic (EEG) recording. We conducted exploratory analyses of the effect of taVNS on P3 amplitudes separately for Draws. We found typical oddball effects on P3 amplitudes at Draws 1 and 2, but not Draw 3. At Draw 2, the oddball effect was enhanced during active compared to sham taVNS stimulation. These data provide evidence that taVNS influences parietal P3 amplitudes under specific circumstances. Only P3 amplitudes at Draw 2 were affected, which may relate to closure of Bayesian inference after Draw 2. Our findings seemingly support previously reported links between taVNS and the NE system.https://www.mdpi.com/2076-3425/10/6/404norepinephrineevent-related potentialstranscutaneous auricular vagal nerve stimulationP300oddballneuromodulation |
| spellingShingle | Claire V. Warren María J. Maraver Alberto de Luca Bruno Kopp The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task Brain Sciences norepinephrine event-related potentials transcutaneous auricular vagal nerve stimulation P300 oddball neuromodulation |
| title | The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task |
| title_full | The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task |
| title_fullStr | The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task |
| title_full_unstemmed | The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task |
| title_short | The Effect of Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) on P3 Event-Related Potentials during a Bayesian Oddball Task |
| title_sort | effect of transcutaneous auricular vagal nerve stimulation tavns on p3 event related potentials during a bayesian oddball task |
| topic | norepinephrine event-related potentials transcutaneous auricular vagal nerve stimulation P300 oddball neuromodulation |
| url | https://www.mdpi.com/2076-3425/10/6/404 |
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