Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action
Diets high in bioactive compounds, such as polyphenols, have been used to mitigate metabolic syndrome (MetS). Polyphenols are a large group of naturally occurring bioactive compounds, classified into two main classes: non-flavonoids and flavonoids. Flavonoids are distributed in foods, such as fruits...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8344 |
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| author | Henrique J. C. B. Gouveia Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Bárbara J. R. Costa-de-Santana José Pérez Villarreal Rosalío Mercado-Camargo Luz Torner Jailane de Souza Aquino Ana E. Toscano Omar Guzmán-Quevedo |
| author_facet | Henrique J. C. B. Gouveia Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Bárbara J. R. Costa-de-Santana José Pérez Villarreal Rosalío Mercado-Camargo Luz Torner Jailane de Souza Aquino Ana E. Toscano Omar Guzmán-Quevedo |
| author_sort | Henrique J. C. B. Gouveia |
| collection | DOAJ |
| description | Diets high in bioactive compounds, such as polyphenols, have been used to mitigate metabolic syndrome (MetS). Polyphenols are a large group of naturally occurring bioactive compounds, classified into two main classes: non-flavonoids and flavonoids. Flavonoids are distributed in foods, such as fruits, vegetables, tea, red wine, and cocoa. Studies have already demonstrated the benefits of flavonoids on the cardiovascular and nervous systems, as well as cancer cells. The present review summarizes the results of clinical studies that evaluated the effects of flavonoids on the components of the MetS and associated complications when offered as supplements over the long term. The results show that flavonoids can significantly modulate several metabolic parameters, such as lipid profile, blood pressure, and blood glucose. Only theaflavin and catechin were unable to affect metabolic parameters. Moreover, only body weight and body mass index were unaltered. Thus, the evidence presented in this systematic review offers bases in support of a flavonoid supplementation, held for at least 3 weeks, as a strategy to improve several metabolic parameters and, consequently, reduce the risk of diseases associated with MetS. This fact becomes stronger due to the rare side effects reported with flavonoids. |
| first_indexed | 2024-03-09T12:34:31Z |
| format | Article |
| id | doaj.art-14ad1287a4e74b309247d9c60d0fa906 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:34:31Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-14ad1287a4e74b309247d9c60d0fa9062023-11-30T22:25:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-07-012315834410.3390/ijms23158344Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of ActionHenrique J. C. B. Gouveia0Mercedes V. Urquiza-Martínez1Raul Manhães-de-Castro2Bárbara J. R. Costa-de-Santana3José Pérez Villarreal4Rosalío Mercado-Camargo5Luz Torner6Jailane de Souza Aquino7Ana E. Toscano8Omar Guzmán-Quevedo9Postgraduate Program in Nutrition, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, PE, BrazilLaboratory of Neuronutrition and Food Engineering, Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61650, Michoacán, MexicoStudies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, BrazilStudies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, BrazilInstituto Tecnológico Superior de Uruapan, Uruapan 60015, Michoacán, MexicoFacultad de Químico Farmacobiología, Universidad Michoacana de San Nicolás de Hidalgo, Morelia 58000, Michoacán, MexicoCentro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Morelia 58330, Michoacán, MexicoLaboratory of Experimental Nutrition, Department of Nutrition, Federal University of Paraiba, João Pessoa 58051-900, PB, BrazilStudies in Nutrition and Phenotypic Plasticity Unit, Department of Nutrition, Federal University of Pernambuco, Recife 50670-901, PE, BrazilLaboratory of Neuronutrition and Food Engineering, Instituto Tecnológico Superior de Tacámbaro, Tacámbaro 61650, Michoacán, MexicoDiets high in bioactive compounds, such as polyphenols, have been used to mitigate metabolic syndrome (MetS). Polyphenols are a large group of naturally occurring bioactive compounds, classified into two main classes: non-flavonoids and flavonoids. Flavonoids are distributed in foods, such as fruits, vegetables, tea, red wine, and cocoa. Studies have already demonstrated the benefits of flavonoids on the cardiovascular and nervous systems, as well as cancer cells. The present review summarizes the results of clinical studies that evaluated the effects of flavonoids on the components of the MetS and associated complications when offered as supplements over the long term. The results show that flavonoids can significantly modulate several metabolic parameters, such as lipid profile, blood pressure, and blood glucose. Only theaflavin and catechin were unable to affect metabolic parameters. Moreover, only body weight and body mass index were unaltered. Thus, the evidence presented in this systematic review offers bases in support of a flavonoid supplementation, held for at least 3 weeks, as a strategy to improve several metabolic parameters and, consequently, reduce the risk of diseases associated with MetS. This fact becomes stronger due to the rare side effects reported with flavonoids.https://www.mdpi.com/1422-0067/23/15/8344biomarkersmetabolic syndromepolyphenolsdyslipidemiaslipid metabolisminsulin resistance |
| spellingShingle | Henrique J. C. B. Gouveia Mercedes V. Urquiza-Martínez Raul Manhães-de-Castro Bárbara J. R. Costa-de-Santana José Pérez Villarreal Rosalío Mercado-Camargo Luz Torner Jailane de Souza Aquino Ana E. Toscano Omar Guzmán-Quevedo Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action International Journal of Molecular Sciences biomarkers metabolic syndrome polyphenols dyslipidemias lipid metabolism insulin resistance |
| title | Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action |
| title_full | Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action |
| title_fullStr | Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action |
| title_full_unstemmed | Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action |
| title_short | Effects of the Treatment with Flavonoids on Metabolic Syndrome Components in Humans: A Systematic Review Focusing on Mechanisms of Action |
| title_sort | effects of the treatment with flavonoids on metabolic syndrome components in humans a systematic review focusing on mechanisms of action |
| topic | biomarkers metabolic syndrome polyphenols dyslipidemias lipid metabolism insulin resistance |
| url | https://www.mdpi.com/1422-0067/23/15/8344 |
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