Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis
Objective: To investigate the causal relationship between poor lifestyle habits, such as smoking and drinking, and cutaneous malignant melanoma. Method: In the present study, alcohol consumption and smoking were used as exposure factors, and single nucleotide polymorphisms closely associated with al...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Gaceta Sanitaria |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0213911123000729 |
| _version_ | 1827582117509332992 |
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| author | Jiaxiang Xu Wenhui Liu Xuanjun Liu Xinlong Zhou Guangshuai Li |
| author_facet | Jiaxiang Xu Wenhui Liu Xuanjun Liu Xinlong Zhou Guangshuai Li |
| author_sort | Jiaxiang Xu |
| collection | DOAJ |
| description | Objective: To investigate the causal relationship between poor lifestyle habits, such as smoking and drinking, and cutaneous malignant melanoma. Method: In the present study, alcohol consumption and smoking were used as exposure factors, and single nucleotide polymorphisms closely associated with alcohol consumption and smoking were used as instrumental variables, while cutaneous melanoma was set as an outcome variable. Two-sample Mendelian randomization analyses were run between alcohol consumption and melanoma and smoking and melanoma to investigate their causal associations, respectively. Results: We found a positive and statistically significant causal effect of alcohol intake on the risk of cutaneous malignant melanoma (OR: 2.23; 95%CI: 1.11-4.47; p = 0.02). The present study showed no significant causal relationship between cigarettes per day and cutaneous melanoma (OR: 0.85; 95%CI: 0.54-1.35; p = 0.50) or smoking initiation and cutaneous melanoma (OR: 1.02; 95%CI: 0.74-1.39; p = 0.88). Conclusions: This study provides Mendelian randomization evidence supporting alcohol consumption as a risk factor for cutaneous malignant melanoma. And the causal relationship between smoking and cutaneous malignant melanoma still needs to be further investigated. Resumen: Objetivo: Investigar la relación causal entre los malos hábitos de vida, como el tabaquismo y el consumo de alcohol, y el melanoma maligno cutáneo. Método: En el presente estudio, el consumo de alcohol y el tabaquismo se utilizaron como factores de exposición, y los polimorfismos de nucleótido único estrechamente asociados con el consumo de alcohol y el tabaquismo se utilizaron como variables instrumentales, mientras que el melanoma cutáneo se estableció como variable de resultado. Se realizaron análisis de aleatorización mendeliana de dos muestras entre el consumo de alcohol y el melanoma, y entre el tabaquismo y el melanoma, para investigar sus asociaciones causales, respectivamente. Resultados: Se encontró un efecto causal positivo y estadísticamente significativo del consumo de alcohol sobre el riesgo de melanoma maligno cutáneo (OR: 2,23; IC95%: 1,11-4,47; p = 0,02). El presente estudio no mostró una relación causal significativa entre cigarrillos por día y melanoma cutáneo (OR: 0,85; IC95%: 0,54-1,35; p = 0,50) ni entre inicio de fumar y melanoma cutáneo (OR: 1,02; IC95%: 0,74-1,39; p = 0,88). Conclusiones: Este estudio aporta pruebas de aleatorización mendeliana que apoyan el consumo de alcohol como factor de riesgo de melanoma maligno cutáneo. En cuanto a la relación causal entre el tabaquismo y el melanoma maligno cutáneo aún debe investigarse más a fondo. |
| first_indexed | 2024-03-08T22:46:51Z |
| format | Article |
| id | doaj.art-14ad5ff9361a48fabe361b8714b9d467 |
| institution | Directory Open Access Journal |
| issn | 0213-9111 |
| language | English |
| last_indexed | 2024-03-08T22:46:51Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gaceta Sanitaria |
| spelling | doaj.art-14ad5ff9361a48fabe361b8714b9d4672023-12-17T06:37:39ZengElsevierGaceta Sanitaria0213-91112023-01-0137102351Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysisJiaxiang Xu0Wenhui Liu1Xuanjun Liu2Xinlong Zhou3Guangshuai Li4The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaCorresponding author.; The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, ChinaObjective: To investigate the causal relationship between poor lifestyle habits, such as smoking and drinking, and cutaneous malignant melanoma. Method: In the present study, alcohol consumption and smoking were used as exposure factors, and single nucleotide polymorphisms closely associated with alcohol consumption and smoking were used as instrumental variables, while cutaneous melanoma was set as an outcome variable. Two-sample Mendelian randomization analyses were run between alcohol consumption and melanoma and smoking and melanoma to investigate their causal associations, respectively. Results: We found a positive and statistically significant causal effect of alcohol intake on the risk of cutaneous malignant melanoma (OR: 2.23; 95%CI: 1.11-4.47; p = 0.02). The present study showed no significant causal relationship between cigarettes per day and cutaneous melanoma (OR: 0.85; 95%CI: 0.54-1.35; p = 0.50) or smoking initiation and cutaneous melanoma (OR: 1.02; 95%CI: 0.74-1.39; p = 0.88). Conclusions: This study provides Mendelian randomization evidence supporting alcohol consumption as a risk factor for cutaneous malignant melanoma. And the causal relationship between smoking and cutaneous malignant melanoma still needs to be further investigated. Resumen: Objetivo: Investigar la relación causal entre los malos hábitos de vida, como el tabaquismo y el consumo de alcohol, y el melanoma maligno cutáneo. Método: En el presente estudio, el consumo de alcohol y el tabaquismo se utilizaron como factores de exposición, y los polimorfismos de nucleótido único estrechamente asociados con el consumo de alcohol y el tabaquismo se utilizaron como variables instrumentales, mientras que el melanoma cutáneo se estableció como variable de resultado. Se realizaron análisis de aleatorización mendeliana de dos muestras entre el consumo de alcohol y el melanoma, y entre el tabaquismo y el melanoma, para investigar sus asociaciones causales, respectivamente. Resultados: Se encontró un efecto causal positivo y estadísticamente significativo del consumo de alcohol sobre el riesgo de melanoma maligno cutáneo (OR: 2,23; IC95%: 1,11-4,47; p = 0,02). El presente estudio no mostró una relación causal significativa entre cigarrillos por día y melanoma cutáneo (OR: 0,85; IC95%: 0,54-1,35; p = 0,50) ni entre inicio de fumar y melanoma cutáneo (OR: 1,02; IC95%: 0,74-1,39; p = 0,88). Conclusiones: Este estudio aporta pruebas de aleatorización mendeliana que apoyan el consumo de alcohol como factor de riesgo de melanoma maligno cutáneo. En cuanto a la relación causal entre el tabaquismo y el melanoma maligno cutáneo aún debe investigarse más a fondo.http://www.sciencedirect.com/science/article/pii/S0213911123000729AlcoholMelanomaTabaquismoAleatorización mendeliana |
| spellingShingle | Jiaxiang Xu Wenhui Liu Xuanjun Liu Xinlong Zhou Guangshuai Li Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis Gaceta Sanitaria Alcohol Melanoma Tabaquismo Aleatorización mendeliana |
| title | Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis |
| title_full | Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis |
| title_fullStr | Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis |
| title_full_unstemmed | Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis |
| title_short | Alcohol drinking, smoking, and cutaneous melanoma risk: Mendelian randomization analysis |
| title_sort | alcohol drinking smoking and cutaneous melanoma risk mendelian randomization analysis |
| topic | Alcohol Melanoma Tabaquismo Aleatorización mendeliana |
| url | http://www.sciencedirect.com/science/article/pii/S0213911123000729 |
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