ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2

ASXL3 gene mutations inhibit cell proliferation and promote cell apoptosis in mouse cardiomyocytes by upregulating lncRNA NONMMUT063967.2

Congenital heart disease (CHD) is a serious condition with unknown etiology. In a recent study, a compound heterozygous mutation (c.3526C > T [p.Arg1176Trp] and c.4643A > G [p.Asp1548Gly]) in the ASXL3 gene was identified, which is associated with CHD. This mutation was overexpressed in HL-1 m...

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Bibliographic Details
Main Authors: Zequn Liu, Yanmin Jiang, Fu Fang, Ru Li, Jin Han, Xin Yang, Qiong Deng, Lu-Shan Li, Ting-ying Lei, Dong-Zhi Li, Can Liao
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
ASXL3 gene mutations
cell proliferation and apoptosis
Cardiomyocytes
lncRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580823000869

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