Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A
Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a tim...
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| Format: | Article |
| Language: | Russian |
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Numikom LLC
2015-04-01
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| Series: | Эпидемиология и вакцинопрофилактика |
| Subjects: | |
| Online Access: | https://www.epidemvac.ru/jour/article/view/45 |
| _version_ | 1797879644841574400 |
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| author | I. V. Dukhovlinov E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev |
| author_facet | I. V. Dukhovlinov E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev |
| author_sort | I. V. Dukhovlinov |
| collection | DOAJ |
| description | Rotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated. |
| first_indexed | 2024-04-10T02:51:45Z |
| format | Article |
| id | doaj.art-14af003a238f4cdcae7289a1d64a7adb |
| institution | Directory Open Access Journal |
| issn | 2073-3046 2619-0494 |
| language | Russian |
| last_indexed | 2024-04-10T02:51:45Z |
| publishDate | 2015-04-01 |
| publisher | Numikom LLC |
| record_format | Article |
| series | Эпидемиология и вакцинопрофилактика |
| spelling | doaj.art-14af003a238f4cdcae7289a1d64a7adb2023-03-13T07:43:11ZrusNumikom LLCЭпидемиология и вакцинопрофилактика2073-30462619-04942015-04-011429610110.31631/2073-3046-2015-14-2-96-10144Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus AI. V. Dukhovlinov0E. G. Bogomolova1E. A. Fedorova2A. S. Simbirtsev3ФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА РоссииФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА РоссииФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА РоссииФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА РоссииRotavirus infection is the leading cause of severe acute diarrhea among young children worldwide. Contagion with these viruses often leads to severe dehydration of organism. Rotaviral gastroenteritis cases may repeat intra vitam. Because of the absence of drugs with direct action on rotavirus, a timely vaccination is considered the most effective way of this disease's control. Nowadays vaccines based on attenuated alive rotaviral strains are used for this purpose, which can result in different complications. In this work the immunogenicity of recombinant fusion proteins VP6VP8 and FliCVP6VP8 - the crucial active agents of the candidate vaccine against rotaviruses - was studied. As part of the study highly purified proteins preparationsin native state were obtained, their high antigenic activity in experiments with laboratory Balb/c mice was demonstrated.https://www.epidemvac.ru/jour/article/view/45ротавирусный гастроэнтеритвакцинарекомбинантные гибридные белкиrotavirus gastroenteritisvaccinerecombinant fusion proteins |
| spellingShingle | I. V. Dukhovlinov E. G. Bogomolova E. A. Fedorova A. S. Simbirtsev Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A Эпидемиология и вакцинопрофилактика ротавирусный гастроэнтерит вакцина рекомбинантные гибридные белки rotavirus gastroenteritis vaccine recombinant fusion proteins |
| title | Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| title_full | Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| title_fullStr | Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| title_full_unstemmed | Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| title_short | Immunogenic Properties Studyoffusion Recombinant Proteins Based on VP6 and VP8 of Human Rotavirus A |
| title_sort | immunogenic properties studyoffusion recombinant proteins based on vp6 and vp8 of human rotavirus a |
| topic | ротавирусный гастроэнтерит вакцина рекомбинантные гибридные белки rotavirus gastroenteritis vaccine recombinant fusion proteins |
| url | https://www.epidemvac.ru/jour/article/view/45 |
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