Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps
Claus Bachert,1,2 Neil Bhattacharyya,3 Martin Desrosiers,4 Asif H Khan1,5 1Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3Department of Otolaryngology, Harvard Medical School, Boston, MA, US...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-02-01
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| Series: | Journal of Asthma and Allergy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/burden-of-disease-in-chronic-rhinosinusitis-with-nasal-polyps-peer-reviewed-article-JAA |
| _version_ | 1818408601825312768 |
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| author | Bachert C Bhattacharyya N Desrosiers M Khan AH |
| author_facet | Bachert C Bhattacharyya N Desrosiers M Khan AH |
| author_sort | Bachert C |
| collection | DOAJ |
| description | Claus Bachert,1,2 Neil Bhattacharyya,3 Martin Desrosiers,4 Asif H Khan1,5 1Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; 4Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada; 5Sanofi, Chilly-Mazarin, FranceCorrespondence: Claus BachertUpper Airways Research Laboratory, Ghent University, C. Heymanslaan 10, Ghent, B-9000, BelgiumTel +32 9 332 6880Email Claus.Bachert@UGent.beAbstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology.Keywords: disease severity, healthcare economics, paranasal sinus disease, quality of life |
| first_indexed | 2024-12-14T09:46:20Z |
| format | Article |
| id | doaj.art-14b00da69ed644a7b4ca0cce2191395a |
| institution | Directory Open Access Journal |
| issn | 1178-6965 |
| language | English |
| last_indexed | 2024-12-14T09:46:20Z |
| publishDate | 2021-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Asthma and Allergy |
| spelling | doaj.art-14b00da69ed644a7b4ca0cce2191395a2022-12-21T23:07:37ZengDove Medical PressJournal of Asthma and Allergy1178-69652021-02-01Volume 1412713461973Burden of Disease in Chronic Rhinosinusitis with Nasal PolypsBachert CBhattacharyya NDesrosiers MKhan AHClaus Bachert,1,2 Neil Bhattacharyya,3 Martin Desrosiers,4 Asif H Khan1,5 1Upper Airways Research Laboratory, Department of Otorhinolaryngology, Ghent University, Ghent, Belgium; 2CLINTEC, Karolinska Institutet, Stockholm, Sweden; 3Department of Otolaryngology, Harvard Medical School, Boston, MA, USA; 4Centre de recherche du Centre hospitalier de l’Université de Montréal (CRCHUM), Montreal, QC, Canada; 5Sanofi, Chilly-Mazarin, FranceCorrespondence: Claus BachertUpper Airways Research Laboratory, Ghent University, C. Heymanslaan 10, Ghent, B-9000, BelgiumTel +32 9 332 6880Email Claus.Bachert@UGent.beAbstract: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a predominantly type 2 inflammation-mediated disease of the nasal mucosa and paranasal sinuses with an under-recognized clinical, humanistic, and economic burden. Patients with CRSwNP experience a high symptom burden, including nasal congestion, loss of smell, and rhinorrhea, which has a negative impact on physical and mental health-related quality of life, including sleep quality. Existing medical and surgical interventions, including local and systemic corticosteroids and endoscopic sinus surgery, may be associated with recurrence of nasal polyps and associated symptoms and with an increased risk of short- and long-term adverse effects, especially with repeated or long-term use. Because type 2 inflammation is implicated in the pathogenesis of several coexisting diseases, patients with CRSwNP often have comorbid asthma and/or nonsteroidal anti-inflammatory drug-exacerbated respiratory disease. These patients, as well as those with high corticosteroid use and/or sinonasal surgical history, have more severe disease and associated symptom burden and represent a difficult-to-treat population under the existing management paradigm. This article reviews the clinical, humanistic, and economic burden of CRSwNP; it highlights the unmet need for effective and safe CRSwNP therapies that effectively control symptoms and minimize recurrence by targeting the underlying type 2 inflammatory disease pathophysiology.Keywords: disease severity, healthcare economics, paranasal sinus disease, quality of lifehttps://www.dovepress.com/burden-of-disease-in-chronic-rhinosinusitis-with-nasal-polyps-peer-reviewed-article-JAAdisease severityhealthcare economicsparanasal sinus diseasequality of life |
| spellingShingle | Bachert C Bhattacharyya N Desrosiers M Khan AH Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps Journal of Asthma and Allergy disease severity healthcare economics paranasal sinus disease quality of life |
| title | Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps |
| title_full | Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps |
| title_fullStr | Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps |
| title_full_unstemmed | Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps |
| title_short | Burden of Disease in Chronic Rhinosinusitis with Nasal Polyps |
| title_sort | burden of disease in chronic rhinosinusitis with nasal polyps |
| topic | disease severity healthcare economics paranasal sinus disease quality of life |
| url | https://www.dovepress.com/burden-of-disease-in-chronic-rhinosinusitis-with-nasal-polyps-peer-reviewed-article-JAA |
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