Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline
A new series of some biologically active Cr(III), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes was synthesized from the reaction of Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate <b>(L)</b> with the previous biological metals in the presence of 1,10-phe...
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MDPI AG
2023-05-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/5/220 |
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| author | Mohamed S. El-Attar Sadeek A. Sadeek Hassan A. El-Sayed Heba M. Kamal Hazem S. Elshafie |
| author_facet | Mohamed S. El-Attar Sadeek A. Sadeek Hassan A. El-Sayed Heba M. Kamal Hazem S. Elshafie |
| author_sort | Mohamed S. El-Attar |
| collection | DOAJ |
| description | A new series of some biologically active Cr(III), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes was synthesized from the reaction of Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate <b>(L)</b> with the previous biological metals in the presence of 1,10-phenanthroline monohydrate (<b>Phen</b>). The structures of the obtained <b>L</b> along with their complexes were authenticated by different analytical and spectral techniques. The data prove that <b>L</b> chelates with all metal ions as bidentate through the nitrogen of the amino group and the nitrogen of the cyano group. Furthermore, <b>Phen</b> chelated with metal ions via two nitrogen atoms. The molar conductance values reflect that all complexes are electrolyte, confirming the 1:3 electrolytic natures for trivalent metal ions and 1:2 electrolytic for bivalent metal ions. The thermal stability and the general thermal decomposition pathways of metal complexes, <b>L,</b> and <b>Phen</b> were evaluating according to the thermogravimetric technique. The activation thermodynamic parameters were estimated from TG curves by utilizing Horowitz–Metzger (HM) and Coats–Redfern (CR) techniques. Powder X-ray diffraction (XRD) analysis proved that <b>L</b>, Cu(II), and Zn(II) compounds have a crystalline nature, whereas, Cr(III), Fe(III), Co(II), and Ni(II) complexes are semicrystalline. The investigated compounds were examined in vitro for their antimicrobial activity towards G(+ve) Staphylococcus aureus and Bacillus subtilis and G(−ve) Escherichia coli and Pseudomonas aeruginosa bacteria, and two fungi: Candida albicans and Aspergillus flavus. According to the findings, the Co(II) complex has a significant efficiency toward bacteria, additionally, Cr(III) complex is highly significant towards fungal strains. |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-11T03:38:11Z |
| publishDate | 2023-05-01 |
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| spelling | doaj.art-14b2940e50c14504abe0c77e6c99d2152023-11-18T01:49:19ZengMDPI AGInorganics2304-67402023-05-0111522010.3390/inorganics11050220Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-PhenanthrolineMohamed S. El-Attar0Sadeek A. Sadeek1Hassan A. El-Sayed2Heba M. Kamal3Hazem S. Elshafie4Department of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, EgyptDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig 44519, EgyptSchool of Agricultural, Forestry, Food and Environmental Sciences, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, ItalyA new series of some biologically active Cr(III), Fe(III), Co(II), Ni(II), Cu(II), and Zn(II) complexes was synthesized from the reaction of Ethyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate <b>(L)</b> with the previous biological metals in the presence of 1,10-phenanthroline monohydrate (<b>Phen</b>). The structures of the obtained <b>L</b> along with their complexes were authenticated by different analytical and spectral techniques. The data prove that <b>L</b> chelates with all metal ions as bidentate through the nitrogen of the amino group and the nitrogen of the cyano group. Furthermore, <b>Phen</b> chelated with metal ions via two nitrogen atoms. The molar conductance values reflect that all complexes are electrolyte, confirming the 1:3 electrolytic natures for trivalent metal ions and 1:2 electrolytic for bivalent metal ions. The thermal stability and the general thermal decomposition pathways of metal complexes, <b>L,</b> and <b>Phen</b> were evaluating according to the thermogravimetric technique. The activation thermodynamic parameters were estimated from TG curves by utilizing Horowitz–Metzger (HM) and Coats–Redfern (CR) techniques. Powder X-ray diffraction (XRD) analysis proved that <b>L</b>, Cu(II), and Zn(II) compounds have a crystalline nature, whereas, Cr(III), Fe(III), Co(II), and Ni(II) complexes are semicrystalline. The investigated compounds were examined in vitro for their antimicrobial activity towards G(+ve) Staphylococcus aureus and Bacillus subtilis and G(−ve) Escherichia coli and Pseudomonas aeruginosa bacteria, and two fungi: Candida albicans and Aspergillus flavus. According to the findings, the Co(II) complex has a significant efficiency toward bacteria, additionally, Cr(III) complex is highly significant towards fungal strains.https://www.mdpi.com/2304-6740/11/5/220nanoparticlesspectroscopyXRDDTAG(+ve) and G(−ve) bacteria |
| spellingShingle | Mohamed S. El-Attar Sadeek A. Sadeek Hassan A. El-Sayed Heba M. Kamal Hazem S. Elshafie Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline Inorganics nanoparticles spectroscopy XRD DTA G(+ve) and G(−ve) bacteria |
| title | Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline |
| title_full | Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline |
| title_fullStr | Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline |
| title_full_unstemmed | Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline |
| title_short | Structural and Antimicrobial Investigation of Some New Nanoparticles Mixed Ligands Metal Complexes of Ethyl 6-Amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate in Presence of 1,10-Phenanthroline |
| title_sort | structural and antimicrobial investigation of some new nanoparticles mixed ligands metal complexes of ethyl 6 amino 4 4 chlorophenyl 5 cyano 2 methyl 4h pyran 3 carboxylate in presence of 1 10 phenanthroline |
| topic | nanoparticles spectroscopy XRD DTA G(+ve) and G(−ve) bacteria |
| url | https://www.mdpi.com/2304-6740/11/5/220 |
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