Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review
IntroductionGraves’ disease (GD) and Graves’ orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic typing, which led to inconsistent results even am...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256922/full |
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| author | Magdalena Stasiak Bartłomiej Stasiak Katarzyna Zawadzka-Starczewska Andrzej Lewiński Andrzej Lewiński |
| author_facet | Magdalena Stasiak Bartłomiej Stasiak Katarzyna Zawadzka-Starczewska Andrzej Lewiński Andrzej Lewiński |
| author_sort | Magdalena Stasiak |
| collection | DOAJ |
| description | IntroductionGraves’ disease (GD) and Graves’ orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic typing, which led to inconsistent results even among the same population. The present review is intended to summarize the state-of-art knowledge on the HLA significance in GD and GO in Asians and Caucasians, as well as to find the most significant alleles for each of the populations. MethodsPubMed was searched for relevant articles using the following search terms: HLA plus thyroid-associated ophthalmopathy or Graves’ disease or Graves’ orbitopathy or thyroid eye disease or thyroid-associated orbitopathy. ResultsIn Asian population GD was found to be associated mostly with B*46:01, DPB1*05:01, DRB1*08:02/03, DRB1*16:02, DRB1*14:03, DRB1*04:05, DQB1*05:02 and DQB1*03:03, while DRB1*07:01, DRB1*01:01, DRB1*13:02, DRB1*12:02 are potentially protective. HLA-B*38:02, DRB1*16:02, DQA1*01:02, DQB1*05:02 can be considered associated with increased risk of GO in Asians, while HLA-B*54:01 may play protective role. In Caucasians, C*07:01, DQA1*05:01, DRB1*03, DQB1*02:01 are associated with GD risk while DRB1*07:01, DQA1*02:01 may be protective. Significance of HLA in the course of GD and novel aspects of HLA amino acid variants and potential HLA-based treatment modalities were also discussed. |
| first_indexed | 2024-03-11T21:17:35Z |
| format | Article |
| id | doaj.art-14b331546e0f45199e4a85ccec5d4f8d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T21:17:35Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Immunology |
| spelling | doaj.art-14b331546e0f45199e4a85ccec5d4f8d2023-09-28T13:23:20ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-09-011410.3389/fimmu.2023.12569221256922Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic reviewMagdalena Stasiak0Bartłomiej Stasiak1Katarzyna Zawadzka-Starczewska2Andrzej Lewiński3Andrzej Lewiński4Department of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, Lodz, PolandInstitute of Information Technology, Lodz University of Technology, Lodz, PolandDepartment of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, Lodz, PolandDepartment of Endocrinology and Metabolic Diseases, Polish Mother’s Memorial Hospital—Research Institute, Lodz, PolandDepartment of Endocrinology and Metabolic Diseases, Medical University of Lodz, Lodz, PolandIntroductionGraves’ disease (GD) and Graves’ orbitopathy (GO) development were suspected to be HLA-related in both Asian and Caucasian populations. However, most studies were performed with application of serological methods or low resolution genetic typing, which led to inconsistent results even among the same population. The present review is intended to summarize the state-of-art knowledge on the HLA significance in GD and GO in Asians and Caucasians, as well as to find the most significant alleles for each of the populations. MethodsPubMed was searched for relevant articles using the following search terms: HLA plus thyroid-associated ophthalmopathy or Graves’ disease or Graves’ orbitopathy or thyroid eye disease or thyroid-associated orbitopathy. ResultsIn Asian population GD was found to be associated mostly with B*46:01, DPB1*05:01, DRB1*08:02/03, DRB1*16:02, DRB1*14:03, DRB1*04:05, DQB1*05:02 and DQB1*03:03, while DRB1*07:01, DRB1*01:01, DRB1*13:02, DRB1*12:02 are potentially protective. HLA-B*38:02, DRB1*16:02, DQA1*01:02, DQB1*05:02 can be considered associated with increased risk of GO in Asians, while HLA-B*54:01 may play protective role. In Caucasians, C*07:01, DQA1*05:01, DRB1*03, DQB1*02:01 are associated with GD risk while DRB1*07:01, DQA1*02:01 may be protective. Significance of HLA in the course of GD and novel aspects of HLA amino acid variants and potential HLA-based treatment modalities were also discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256922/fullGraves’ diseaseGraves’ orbitopathyhuman leukocyte antigenHLAAsian populationCaucasian population |
| spellingShingle | Magdalena Stasiak Bartłomiej Stasiak Katarzyna Zawadzka-Starczewska Andrzej Lewiński Andrzej Lewiński Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review Frontiers in Immunology Graves’ disease Graves’ orbitopathy human leukocyte antigen HLA Asian population Caucasian population |
| title | Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review |
| title_full | Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review |
| title_fullStr | Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review |
| title_full_unstemmed | Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review |
| title_short | Significance of HLA in Graves’ disease and Graves’ orbitopathy in Asian and Caucasian populations – a systematic review |
| title_sort | significance of hla in graves disease and graves orbitopathy in asian and caucasian populations a systematic review |
| topic | Graves’ disease Graves’ orbitopathy human leukocyte antigen HLA Asian population Caucasian population |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256922/full |
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