Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy
Results of the study for anticancer efficacy of photodynamic therapy with chlorin e6 dimethyl ether for treatment of outbread rats with sarcoma M-1 are represented. The drug was given intravenously or intraperitonealy at a dose of 1.25 mg/kg body weight (light dose – 300 J/cm2) or 2,5 mg/kg body wei...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2014-06-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/31 |
| _version_ | 1797883689645899776 |
|---|---|
| author | M. A. Kaplan V. P. Zorin A. I. Malygina I. V. Kashirtseva L. M. Arkhipova |
| author_facet | M. A. Kaplan V. P. Zorin A. I. Malygina I. V. Kashirtseva L. M. Arkhipova |
| author_sort | M. A. Kaplan |
| collection | DOAJ |
| description | Results of the study for anticancer efficacy of photodynamic therapy with chlorin e6 dimethyl ether for treatment of outbread rats with sarcoma M-1 are represented. The drug was given intravenously or intraperitonealy at a dose of 1.25 mg/kg body weight (light dose – 300 J/cm2) or 2,5 mg/kg body weight (light dose – 150 J/cm2). The spectrometry showed that maximal drug accumulation in tumor was in 2 h after intravenous injection or 3 h after intraperitoneal injection of photosensitizer, thus, sensitized tumors were irradiated according to these time intervals. Intraperitoneal injection of chlorin е6 dimethyl ether at a dose of 1.25 mg/kg body weight with treatment session in 3 h and light dose of 300 J/cm2 was the most effective (the complete response in animals – 86%). |
| first_indexed | 2024-04-10T03:55:39Z |
| format | Article |
| id | doaj.art-14b433fbcaa84d1586b7de4c5508f694 |
| institution | Directory Open Access Journal |
| issn | 2413-9432 |
| language | Russian |
| last_indexed | 2024-04-10T03:55:39Z |
| publishDate | 2014-06-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj.art-14b433fbcaa84d1586b7de4c5508f6942023-03-13T07:12:29ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322014-06-013281131Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapyM. A. Kaplan0V. P. Zorin1A. I. Malygina2I. V. Kashirtseva3L. M. Arkhipova4Национальный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияФГБУ «Медицинский Радиологический научный центр» МЗ РФ, г. ОбнинскНациональный медицинский исследовательский радиологический центр Минздрава России, Москва, РоссияResults of the study for anticancer efficacy of photodynamic therapy with chlorin e6 dimethyl ether for treatment of outbread rats with sarcoma M-1 are represented. The drug was given intravenously or intraperitonealy at a dose of 1.25 mg/kg body weight (light dose – 300 J/cm2) or 2,5 mg/kg body weight (light dose – 150 J/cm2). The spectrometry showed that maximal drug accumulation in tumor was in 2 h after intravenous injection or 3 h after intraperitoneal injection of photosensitizer, thus, sensitized tumors were irradiated according to these time intervals. Intraperitoneal injection of chlorin е6 dimethyl ether at a dose of 1.25 mg/kg body weight with treatment session in 3 h and light dose of 300 J/cm2 was the most effective (the complete response in animals – 86%).https://www.pdt-journal.com/jour/article/view/31противоопухолевая эффективностьфотодинамическая терапияфотодинамическое воздействиедиэтиловый эфир хлорина е6 |
| spellingShingle | M. A. Kaplan V. P. Zorin A. I. Malygina I. V. Kashirtseva L. M. Arkhipova Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy Biomedical Photonics противоопухолевая эффективность фотодинамическая терапия фотодинамическое воздействие диэтиловый эфир хлорина е6 |
| title | Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| title_full | Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| title_fullStr | Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| title_full_unstemmed | Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| title_short | Assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| title_sort | assessment of anticancer effect of chlorin e6 dimethyl ether for photodynamic therapy |
| topic | противоопухолевая эффективность фотодинамическая терапия фотодинамическое воздействие диэтиловый эфир хлорина е6 |
| url | https://www.pdt-journal.com/jour/article/view/31 |
| work_keys_str_mv | AT makaplan assessmentofanticancereffectofchlorine6dimethyletherforphotodynamictherapy AT vpzorin assessmentofanticancereffectofchlorine6dimethyletherforphotodynamictherapy AT aimalygina assessmentofanticancereffectofchlorine6dimethyletherforphotodynamictherapy AT ivkashirtseva assessmentofanticancereffectofchlorine6dimethyletherforphotodynamictherapy AT lmarkhipova assessmentofanticancereffectofchlorine6dimethyletherforphotodynamictherapy |