Non-viral gene therapy that targets motor neurons in vivo

Non-viral gene therapy that targets motor neurons in vivo

A major challenge in neurological gene therapy is safe delivery of transgenes to sufficient cell numbers from the circulation or periphery. This is particularly difficult for diseases involving spinal cord motor neurons such as amyotrophic lateral sclerosis (ALS). We have examined the feasibility of...

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Bibliographic Details
Main Authors: Mary-Louise eRogers, Kevin Sean Smith, Dusan eMatusica, Matthew eFenech, Lee eHoffman, Robert Archer Rush, Nicolas Hans Voelcker
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
retrograde transport
targeted gene delivery
PEGylation
PEI
p75NTR
immunogenes
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00080/full

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