Non-Human Primate Models of Orthopoxvirus Infections
Smallpox, one of the most destructive diseases, has been successfully eradicated through a worldwide vaccination campaign. Since immunization programs have been stopped, the number of people with vaccinia virus induced immunity is declining. This leads to an increase in orthopoxvirus (OPXV) infectio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2306-7381/1/1/40 |
| _version_ | 1818724794229587968 |
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| author | Anne Schmitt Kerstin Mätz-Rensing Franz-Josef Kaup |
| author_facet | Anne Schmitt Kerstin Mätz-Rensing Franz-Josef Kaup |
| author_sort | Anne Schmitt |
| collection | DOAJ |
| description | Smallpox, one of the most destructive diseases, has been successfully eradicated through a worldwide vaccination campaign. Since immunization programs have been stopped, the number of people with vaccinia virus induced immunity is declining. This leads to an increase in orthopoxvirus (OPXV) infections in humans, as well as in animals. Additionally, potential abuse of Variola virus (VARV), the causative agent of smallpox, or monkeypox virus, as agents of bioterrorism, has renewed interest in development of antiviral therapeutics and of safer vaccines. Due to its high risk potential, research with VARV is restricted to two laboratories worldwide. Therefore, numerous animal models of other OPXV infections have been developed in the last decades. Non-human primates are especially suitable due to their close relationship to humans. This article provides a review about on non-human primate models of orthopoxvirus infections. |
| first_indexed | 2024-12-17T21:32:04Z |
| format | Article |
| id | doaj.art-14b7725939a946dd93854eba648672de |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-17T21:32:04Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-14b7725939a946dd93854eba648672de2022-12-21T21:31:50ZengMDPI AGVeterinary Sciences2306-73812014-06-0111406210.3390/vetsci1010040vetsci1010040Non-Human Primate Models of Orthopoxvirus InfectionsAnne Schmitt0Kerstin Mätz-Rensing1Franz-Josef Kaup2Pathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, GermanyPathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, GermanyPathology Unit, German Primate Center, Leibniz Institute for Primate Research, Kellnerweg 4, 37077 Göttingen, GermanySmallpox, one of the most destructive diseases, has been successfully eradicated through a worldwide vaccination campaign. Since immunization programs have been stopped, the number of people with vaccinia virus induced immunity is declining. This leads to an increase in orthopoxvirus (OPXV) infections in humans, as well as in animals. Additionally, potential abuse of Variola virus (VARV), the causative agent of smallpox, or monkeypox virus, as agents of bioterrorism, has renewed interest in development of antiviral therapeutics and of safer vaccines. Due to its high risk potential, research with VARV is restricted to two laboratories worldwide. Therefore, numerous animal models of other OPXV infections have been developed in the last decades. Non-human primates are especially suitable due to their close relationship to humans. This article provides a review about on non-human primate models of orthopoxvirus infections.http://www.mdpi.com/2306-7381/1/1/40non-human primatesmallpoxmonkeypoxcowpoxanimal models |
| spellingShingle | Anne Schmitt Kerstin Mätz-Rensing Franz-Josef Kaup Non-Human Primate Models of Orthopoxvirus Infections Veterinary Sciences non-human primate smallpox monkeypox cowpox animal models |
| title | Non-Human Primate Models of Orthopoxvirus Infections |
| title_full | Non-Human Primate Models of Orthopoxvirus Infections |
| title_fullStr | Non-Human Primate Models of Orthopoxvirus Infections |
| title_full_unstemmed | Non-Human Primate Models of Orthopoxvirus Infections |
| title_short | Non-Human Primate Models of Orthopoxvirus Infections |
| title_sort | non human primate models of orthopoxvirus infections |
| topic | non-human primate smallpox monkeypox cowpox animal models |
| url | http://www.mdpi.com/2306-7381/1/1/40 |
| work_keys_str_mv | AT anneschmitt nonhumanprimatemodelsoforthopoxvirusinfections AT kerstinmatzrensing nonhumanprimatemodelsoforthopoxvirusinfections AT franzjosefkaup nonhumanprimatemodelsoforthopoxvirusinfections |