Capturing the unpredictability of stem cells
A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2024-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/95513 |
| _version_ | 1797289162543464448 |
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| author | Arda Durmaz Valeria Visconte |
| author_facet | Arda Durmaz Valeria Visconte |
| author_sort | Arda Durmaz |
| collection | DOAJ |
| description | A new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells. |
| first_indexed | 2024-03-07T19:00:43Z |
| format | Article |
| id | doaj.art-14b8323392434634bc825a071f1e90a3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-03-07T19:00:43Z |
| publishDate | 2024-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-14b8323392434634bc825a071f1e90a32024-03-01T14:52:42ZengeLife Sciences Publications LtdeLife2050-084X2024-03-011310.7554/eLife.95513Capturing the unpredictability of stem cellsArda Durmaz0Valeria Visconte1https://orcid.org/0000-0002-2993-1509Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, United StatesDepartment of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, United StatesA new mathematical model that can be applied to both single-cell and bulk DNA sequencing data sheds light on the processes governing population dynamics in stem cells.https://elifesciences.org/articles/95513healthy human tissuesstem cell dynamicssingle cell mutation burdenvariant allele frequencysamplingevolutionary inferences |
| spellingShingle | Arda Durmaz Valeria Visconte Capturing the unpredictability of stem cells eLife healthy human tissues stem cell dynamics single cell mutation burden variant allele frequency sampling evolutionary inferences |
| title | Capturing the unpredictability of stem cells |
| title_full | Capturing the unpredictability of stem cells |
| title_fullStr | Capturing the unpredictability of stem cells |
| title_full_unstemmed | Capturing the unpredictability of stem cells |
| title_short | Capturing the unpredictability of stem cells |
| title_sort | capturing the unpredictability of stem cells |
| topic | healthy human tissues stem cell dynamics single cell mutation burden variant allele frequency sampling evolutionary inferences |
| url | https://elifesciences.org/articles/95513 |
| work_keys_str_mv | AT ardadurmaz capturingtheunpredictabilityofstemcells AT valeriavisconte capturingtheunpredictabilityofstemcells |