Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial
Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supple...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/5/1362 |
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| author | Dean Wu Cheng-Chang Yang Kuan-Yu Chen Ying-Chin Lin Pei-Jung Wu Pei-Hsiu Hsieh Yoshihiro Nakao Mandy Y. L. Ow Yi-Chen Hsieh Chaur-Jong Hu |
| author_facet | Dean Wu Cheng-Chang Yang Kuan-Yu Chen Ying-Chin Lin Pei-Jung Wu Pei-Hsiu Hsieh Yoshihiro Nakao Mandy Y. L. Ow Yi-Chen Hsieh Chaur-Jong Hu |
| author_sort | Dean Wu |
| collection | DOAJ |
| description | Cognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of ProBeptigen<sup>®</sup> (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the ProBeptigen<sup>®</sup> or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The ProBeptigen<sup>®</sup> group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of ProBeptigen<sup>®</sup> in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of ProBeptigen<sup>®</sup> is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of ProBeptigen<sup>®</sup> on cognition warrant further investigation. (NCT03612752) |
| first_indexed | 2024-03-10T19:55:09Z |
| format | Article |
| id | doaj.art-14ba10f3ab7d4f53a3b77ba500faef62 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:55:09Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-14ba10f3ab7d4f53a3b77ba500faef622023-11-19T23:58:29ZengMDPI AGNutrients2072-66432020-05-01125136210.3390/nu12051362Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind TrialDean Wu0Cheng-Chang Yang1Kuan-Yu Chen2Ying-Chin Lin3Pei-Jung Wu4Pei-Hsiu Hsieh5Yoshihiro Nakao6Mandy Y. L. Ow7Yi-Chen Hsieh8Chaur-Jong Hu9Department of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanDepartment of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanDepartment of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanSchool of Medicine, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanDepartment of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanResearch and Development, BRAND’S Suntory Asia, Singapore 138623, SingaporeResearch and Development, BRAND’S Suntory Asia, Singapore 138623, SingaporePhD Program for Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 110, TaiwanDepartment of Neurology, Shuang-Ho Hospital, Taipei Medical University, New Taipei 235, TaiwanCognitive decline is an important issue of global public health. Cognitive aging might begin at middle adulthood, the period particularly vulnerable to stress in lifespan. Essence of chicken (EOC) has consistently demonstrated its beneficial effects on various cognitive domains as nutritional supplementation. This study primarily aimed to examine the cognitive enhancement effects of ProBeptigen<sup>®</sup> (previously named CMI-168), hydrolyzed peptides extracted from EOC, in healthy middle-aged people under mild stress. Ninety healthy subjects were randomly assigned into the ProBeptigen<sup>®</sup> or placebo group for eight weeks. Neurocognitive assessment, event-related potentials (ERPs), and blood tests were conducted before, during, and after the treatment. The ProBeptigen<sup>®</sup> group outperformed placebo group on Logical Memory subtests of Wechsler Memory Scale-third edition (WMS-III) and Spatial Working Memory task in the Cambridge Neuropsychological Test Automated Battery (CANTAB). The anti-inflammatory effects of ProBeptigen<sup>®</sup> in humans were also confirmed, with progressively declining high-sensitivity C-reactive protein (hs-CRP) levels. Regular dietary supplementation of ProBeptigen<sup>®</sup> is suggested to improve verbal short- and long-term memory as well as spatial working memory, and reduce inflammation in middle-aged healthy individuals with stress. The effects of ProBeptigen<sup>®</sup> on cognition warrant further investigation. (NCT03612752)https://www.mdpi.com/2072-6643/12/5/1362dietary supplementscognitive declineessence of chicken |
| spellingShingle | Dean Wu Cheng-Chang Yang Kuan-Yu Chen Ying-Chin Lin Pei-Jung Wu Pei-Hsiu Hsieh Yoshihiro Nakao Mandy Y. L. Ow Yi-Chen Hsieh Chaur-Jong Hu Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial Nutrients dietary supplements cognitive decline essence of chicken |
| title | Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial |
| title_full | Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial |
| title_fullStr | Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial |
| title_full_unstemmed | Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial |
| title_short | Hydrolyzed Chicken Extract (ProBeptigen<sup>®</sup>) on Cognitive Function in Healthy Middle-Aged People: A Randomized Double-Blind Trial |
| title_sort | hydrolyzed chicken extract probeptigen sup r sup on cognitive function in healthy middle aged people a randomized double blind trial |
| topic | dietary supplements cognitive decline essence of chicken |
| url | https://www.mdpi.com/2072-6643/12/5/1362 |
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