Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors
In recent years, the incidence of various types of tumors has gradually increased, and it has also been found that there is a certain correlation between abnormal glucose and lipid metabolism and tumors. Glycolipid metabolism can promote tumor progression through multiple pathways, and the expressio...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2021-01-01
|
| Series: | Drug Delivery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10717544.2021.1995081 |
| _version_ | 1819279577799720960 |
|---|---|
| author | Xianhu Zeng Zhipeng Li Chunrong Zhu Lisa Xu Yong Sun Shangcong Han |
| author_facet | Xianhu Zeng Zhipeng Li Chunrong Zhu Lisa Xu Yong Sun Shangcong Han |
| author_sort | Xianhu Zeng |
| collection | DOAJ |
| description | In recent years, the incidence of various types of tumors has gradually increased, and it has also been found that there is a certain correlation between abnormal glucose and lipid metabolism and tumors. Glycolipid metabolism can promote tumor progression through multiple pathways, and the expression of related genes also directly or indirectly affects tumor metabolism, metastasis, invasion, and apoptosis. There has been much research on targeted drug delivery systems designed for abnormal glucose and lipid metabolism due to their accuracy and efficiency when used for tumor therapy. In addition, gene mutations have become an important factor in tumorigenesis. For this reason, gene therapy consisting of drugs designed for certain specifically expressed genes have been transfected into target cells to express or silence the corresponding proteins. Targeted gene drug vectors that achieve their corresponding therapeutic purposes are also rapidly developing. The genes related to glucose and lipid metabolism are considered as the target, and a corresponding gene drug carrier is constructed to influence and interfere with the expression of related genes, so as to block the tumorigenesis process and inhibit tumor growth. Designing drugs that target genes related to glucose and lipid metabolism within tumors is considered to be a promising strategy for the treatment of tumor diseases. This article summarizes the chemical drugs/gene drug delivery systems and the corresponding methods used in recent years for the treatment of abnormal glucose and lipid metabolism of tumors, and provides a theoretical basis for the development of glucolipid metabolism related therapeutic methods. |
| first_indexed | 2024-12-24T00:30:07Z |
| format | Article |
| id | doaj.art-14bb6a3ee1f946eeb3d445ba20ca82ca |
| institution | Directory Open Access Journal |
| issn | 1071-7544 1521-0464 |
| language | English |
| last_indexed | 2024-12-24T00:30:07Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Drug Delivery |
| spelling | doaj.art-14bb6a3ee1f946eeb3d445ba20ca82ca2022-12-21T17:24:17ZengTaylor & Francis GroupDrug Delivery1071-75441521-04642021-01-012812329234710.1080/10717544.2021.19950811995081Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumorsXianhu Zeng0Zhipeng Li1Chunrong Zhu2Lisa Xu3Yong Sun4Shangcong Han5Department of Pharmaceutics, School of Pharmacy, Qingdao UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversitySchool of Public Health, Qingdao UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversityDepartment of Pharmaceutics, School of Pharmacy, Qingdao UniversityIn recent years, the incidence of various types of tumors has gradually increased, and it has also been found that there is a certain correlation between abnormal glucose and lipid metabolism and tumors. Glycolipid metabolism can promote tumor progression through multiple pathways, and the expression of related genes also directly or indirectly affects tumor metabolism, metastasis, invasion, and apoptosis. There has been much research on targeted drug delivery systems designed for abnormal glucose and lipid metabolism due to their accuracy and efficiency when used for tumor therapy. In addition, gene mutations have become an important factor in tumorigenesis. For this reason, gene therapy consisting of drugs designed for certain specifically expressed genes have been transfected into target cells to express or silence the corresponding proteins. Targeted gene drug vectors that achieve their corresponding therapeutic purposes are also rapidly developing. The genes related to glucose and lipid metabolism are considered as the target, and a corresponding gene drug carrier is constructed to influence and interfere with the expression of related genes, so as to block the tumorigenesis process and inhibit tumor growth. Designing drugs that target genes related to glucose and lipid metabolism within tumors is considered to be a promising strategy for the treatment of tumor diseases. This article summarizes the chemical drugs/gene drug delivery systems and the corresponding methods used in recent years for the treatment of abnormal glucose and lipid metabolism of tumors, and provides a theoretical basis for the development of glucolipid metabolism related therapeutic methods.http://dx.doi.org/10.1080/10717544.2021.1995081targeted nano-drug carrierabnormal glucose and lipid metabolismgene carrier drugstumors |
| spellingShingle | Xianhu Zeng Zhipeng Li Chunrong Zhu Lisa Xu Yong Sun Shangcong Han Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors Drug Delivery targeted nano-drug carrier abnormal glucose and lipid metabolism gene carrier drugs tumors |
| title | Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| title_full | Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| title_fullStr | Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| title_full_unstemmed | Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| title_short | Research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| title_sort | research progress of nanocarriers for gene therapy targeting abnormal glucose and lipid metabolism in tumors |
| topic | targeted nano-drug carrier abnormal glucose and lipid metabolism gene carrier drugs tumors |
| url | http://dx.doi.org/10.1080/10717544.2021.1995081 |
| work_keys_str_mv | AT xianhuzeng researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors AT zhipengli researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors AT chunrongzhu researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors AT lisaxu researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors AT yongsun researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors AT shangconghan researchprogressofnanocarriersforgenetherapytargetingabnormalglucoseandlipidmetabolismintumors |