Nucleocytoplasmic Shuttling of Influenza A Virus Proteins
Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-05-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/7/5/2668 |
| _version_ | 1828896145636589568 |
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| author | Jing Li Meng Yu Weinan Zheng Wenjun Liu |
| author_facet | Jing Li Meng Yu Weinan Zheng Wenjun Liu |
| author_sort | Jing Li |
| collection | DOAJ |
| description | Influenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses. |
| first_indexed | 2024-12-13T14:38:26Z |
| format | Article |
| id | doaj.art-14bbc0fc1bec4bc1b044ae89205b49f0 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-13T14:38:26Z |
| publishDate | 2015-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-14bbc0fc1bec4bc1b044ae89205b49f02022-12-21T23:41:40ZengMDPI AGViruses1999-49152015-05-01752668268210.3390/v7052668v7052668Nucleocytoplasmic Shuttling of Influenza A Virus ProteinsJing Li0Meng Yu1Weinan Zheng2Wenjun Liu3Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaKey Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, ChinaInfluenza viruses transcribe and replicate their genomes in the nuclei of infected host cells. The viral ribonucleoprotein (vRNP) complex of influenza virus is the essential genetic unit of the virus. The viral proteins play important roles in multiple processes, including virus structural maintenance, mediating nucleocytoplasmic shuttling of the vRNP complex, virus particle assembly, and budding. Nucleocytoplasmic shuttling of viral proteins occurs throughout the entire virus life cycle. This review mainly focuses on matrix protein (M1), nucleoprotein (NP), nonstructural protein (NS1), and nuclear export protein (NEP), summarizing the mechanisms of their nucleocytoplasmic shuttling and the regulation of virus replication through their phosphorylation to further understand the regulation of nucleocytoplasmic shuttling in host adaptation of the viruses.http://www.mdpi.com/1999-4915/7/5/2668influenza A virusnucleocytoplasmic shuttlingvirus replication |
| spellingShingle | Jing Li Meng Yu Weinan Zheng Wenjun Liu Nucleocytoplasmic Shuttling of Influenza A Virus Proteins Viruses influenza A virus nucleocytoplasmic shuttling virus replication |
| title | Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
| title_full | Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
| title_fullStr | Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
| title_full_unstemmed | Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
| title_short | Nucleocytoplasmic Shuttling of Influenza A Virus Proteins |
| title_sort | nucleocytoplasmic shuttling of influenza a virus proteins |
| topic | influenza A virus nucleocytoplasmic shuttling virus replication |
| url | http://www.mdpi.com/1999-4915/7/5/2668 |
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