Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023
The spread of antimicrobial resistant <i>Campylobacter</i> strains, linked to antimicrobials use and abuse in humans and food animals, has become a global public health problem. In this study, we determine the prevalence of antimicrobial resistance (AMR) in human <i>Campylobacter&l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/12/3/426 |
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| author | Clara Tramuta Aitor Garcia-Vozmediano CeRTiS Clinical Laboratories Group Cristiana Maurella Daniela Manila Bianchi Lucia Decastelli Monica Pitti |
| author_facet | Clara Tramuta Aitor Garcia-Vozmediano CeRTiS Clinical Laboratories Group Cristiana Maurella Daniela Manila Bianchi Lucia Decastelli Monica Pitti |
| author_sort | Clara Tramuta |
| collection | DOAJ |
| description | The spread of antimicrobial resistant <i>Campylobacter</i> strains, linked to antimicrobials use and abuse in humans and food animals, has become a global public health problem. In this study, we determine the prevalence of antimicrobial resistance (AMR) in human <i>Campylobacter</i> isolates (n = 820) collected in Piedmont, Italy, from March 2020 to July 2023. The strains underwent susceptibility testing to determine the minimal inhibitory concentration for erythromycin, ciprofloxacin, gentamicin, streptomycin, and tetracycline: 80.1% of the strains showed resistance to at least one antibiotic. The highest prevalence of AMR was noted for ciprofloxacin and tetracycline (72.1% and 52.9%, respectively) and the lowest for erythromycin and aminoglycosides (streptomycin/gentamicin) (3.2% and 5.4%, respectively). The prevalence of co-resistance against fluoroquinolones and tetracyclines was 41.1%. The prevalence of multidrug resistant strains was 5.7%. Our data support evidence that AMR in human <i>Campylobacter</i> strains is common, particularly against ciprofloxacin and tetracycline, two medically important antimicrobials for humans. |
| first_indexed | 2024-04-24T18:00:05Z |
| format | Article |
| id | doaj.art-14be2dacc50e409ca4e46304622ef015 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-04-24T18:00:05Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-14be2dacc50e409ca4e46304622ef0152024-03-27T13:55:26ZengMDPI AGMicroorganisms2076-26072024-02-0112342610.3390/microorganisms12030426Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023Clara Tramuta0Aitor Garcia-Vozmediano1CeRTiS Clinical Laboratories GroupCristiana Maurella2Daniela Manila Bianchi3Lucia Decastelli4Monica Pitti5Centro di Riferimento per la Tipizzazione delle Salmonelle, CeRTiS, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyS.S. Rischi Alimentari ed Epidemiologia degli Alimenti (REA), Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyS.S. Rischi Alimentari ed Epidemiologia degli Alimenti (REA), Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyCentro di Riferimento per la Tipizzazione delle Salmonelle, CeRTiS, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyCentro di Riferimento per la Tipizzazione delle Salmonelle, CeRTiS, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyCentro di Riferimento per la Tipizzazione delle Salmonelle, CeRTiS, Istituto Zooprofilattico Sperimentale del Piemonte Liguria e Valle d’Aosta, Via Bologna, 148, 10154 Turin, ItalyThe spread of antimicrobial resistant <i>Campylobacter</i> strains, linked to antimicrobials use and abuse in humans and food animals, has become a global public health problem. In this study, we determine the prevalence of antimicrobial resistance (AMR) in human <i>Campylobacter</i> isolates (n = 820) collected in Piedmont, Italy, from March 2020 to July 2023. The strains underwent susceptibility testing to determine the minimal inhibitory concentration for erythromycin, ciprofloxacin, gentamicin, streptomycin, and tetracycline: 80.1% of the strains showed resistance to at least one antibiotic. The highest prevalence of AMR was noted for ciprofloxacin and tetracycline (72.1% and 52.9%, respectively) and the lowest for erythromycin and aminoglycosides (streptomycin/gentamicin) (3.2% and 5.4%, respectively). The prevalence of co-resistance against fluoroquinolones and tetracyclines was 41.1%. The prevalence of multidrug resistant strains was 5.7%. Our data support evidence that AMR in human <i>Campylobacter</i> strains is common, particularly against ciprofloxacin and tetracycline, two medically important antimicrobials for humans.https://www.mdpi.com/2076-2607/12/3/426antimicrobial susceptibility testing<i>Campylobacter jejuni</i><i>Campylobacter coli</i>foodborne pathogenshuman strainsoccurrence |
| spellingShingle | Clara Tramuta Aitor Garcia-Vozmediano CeRTiS Clinical Laboratories Group Cristiana Maurella Daniela Manila Bianchi Lucia Decastelli Monica Pitti Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 Microorganisms antimicrobial susceptibility testing <i>Campylobacter jejuni</i> <i>Campylobacter coli</i> foodborne pathogens human strains occurrence |
| title | Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 |
| title_full | Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 |
| title_fullStr | Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 |
| title_full_unstemmed | Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 |
| title_short | Phenotypic Antimicrobial Resistance Profiles of Human <i>Campylobacter</i> Species Isolated in Northwest Italy, 2020–2023 |
| title_sort | phenotypic antimicrobial resistance profiles of human i campylobacter i species isolated in northwest italy 2020 2023 |
| topic | antimicrobial susceptibility testing <i>Campylobacter jejuni</i> <i>Campylobacter coli</i> foodborne pathogens human strains occurrence |
| url | https://www.mdpi.com/2076-2607/12/3/426 |
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