Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa
Objective To investigate the retinal function corresponding to retinal structure by microperimetry and spectral-domain optical coherence tomography (SD-OCT) for the macular area in the patients with primary retinitis pigmentosa (RP). Methods A retrospective analysis was performed among 23 patients (...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of Third Military Medical University
2019-02-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/201808050.htm |
| _version_ | 1818404642515582976 |
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| author | GU Peng HUO Shujia WANG Qing SUN Cheng LIU Yong |
| author_facet | GU Peng HUO Shujia WANG Qing SUN Cheng LIU Yong |
| author_sort | GU Peng |
| collection | DOAJ |
| description | Objective To investigate the retinal function corresponding to retinal structure by microperimetry and spectral-domain optical coherence tomography (SD-OCT) for the macular area in the patients with primary retinitis pigmentosa (RP). Methods A retrospective analysis was performed among 23 patients (46 eyes) diagnosed with RP in our department from January 2015 to December 2017. The results of visual acuity, SD-OCT in the macular area and microperimetry were collected and analyzed. The correlation of best corrected visual acuity, retinal sensitivity and retinal thickness was analyzed. Results The retinal sensitivity in the range of 10° around the fovea by microperimetry was related to the total retinal thickness of the corresponding area detected by SD-OCT (nasal 3°, 5°: r=0.462, P < 0.05; r=0.350, P < 0.05; temporal 3°, 5°: r=0.494, P < 0.05; r=0.426, P < 0.05), and was significantly correlated with outer retinal thickness (nasal 3°, 5°: r=0.718, P < 0.05; r=0.643, P < 0.05; temporal 3°, 5°: r=0.639, P < 0.05; r=0.564, P < 0.05), but not with inner outer retinal thickness. The best corrected visual acuity and the sensitivity of central macular was significantly correlated (r=0.682, P < 0.05). Conclusion The combination of microperimetry and SD-OCT can effectively evaluate the retinal function and morphological characteristics of RP patients. The changes of microperimetric parameters are mainly related to photoreceptor cell apoptosis, which can be used as an indicator to judge photoreceptor function changes during RP lesions. |
| first_indexed | 2024-12-14T08:43:24Z |
| format | Article |
| id | doaj.art-14c31be00b394b38b5462ad99106e49f |
| institution | Directory Open Access Journal |
| issn | 1000-5404 |
| language | zho |
| last_indexed | 2024-12-14T08:43:24Z |
| publishDate | 2019-02-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
| record_format | Article |
| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-14c31be00b394b38b5462ad99106e49f2022-12-21T23:09:14ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042019-02-0141324725110.16016/j.1000-5404.201808050Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosaGU Peng0HUO Shujia1WANG Qing2SUN Cheng3LIU Yong4Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Department of Ophthalmology, First Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400038, China Objective To investigate the retinal function corresponding to retinal structure by microperimetry and spectral-domain optical coherence tomography (SD-OCT) for the macular area in the patients with primary retinitis pigmentosa (RP). Methods A retrospective analysis was performed among 23 patients (46 eyes) diagnosed with RP in our department from January 2015 to December 2017. The results of visual acuity, SD-OCT in the macular area and microperimetry were collected and analyzed. The correlation of best corrected visual acuity, retinal sensitivity and retinal thickness was analyzed. Results The retinal sensitivity in the range of 10° around the fovea by microperimetry was related to the total retinal thickness of the corresponding area detected by SD-OCT (nasal 3°, 5°: r=0.462, P < 0.05; r=0.350, P < 0.05; temporal 3°, 5°: r=0.494, P < 0.05; r=0.426, P < 0.05), and was significantly correlated with outer retinal thickness (nasal 3°, 5°: r=0.718, P < 0.05; r=0.643, P < 0.05; temporal 3°, 5°: r=0.639, P < 0.05; r=0.564, P < 0.05), but not with inner outer retinal thickness. The best corrected visual acuity and the sensitivity of central macular was significantly correlated (r=0.682, P < 0.05). Conclusion The combination of microperimetry and SD-OCT can effectively evaluate the retinal function and morphological characteristics of RP patients. The changes of microperimetric parameters are mainly related to photoreceptor cell apoptosis, which can be used as an indicator to judge photoreceptor function changes during RP lesions.http://aammt.tmmu.edu.cn/Upload/rhtml/201808050.htmretinitis pigmentosamacular areaoptical coherence tomographymicroperimetry |
| spellingShingle | GU Peng HUO Shujia WANG Qing SUN Cheng LIU Yong Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa Di-san junyi daxue xuebao retinitis pigmentosa macular area optical coherence tomography microperimetry |
| title | Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| title_full | Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| title_fullStr | Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| title_full_unstemmed | Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| title_short | Correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| title_sort | correlation of microperimetric parameters with retinal structure in patients with retinitis pigmentosa |
| topic | retinitis pigmentosa macular area optical coherence tomography microperimetry |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/201808050.htm |
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