Simulating auditory nerve fiber response following micro-electrode stimulation
The cochlear implant was the first effective and is still the most common neuroprosthetic device which is employed for people with severe to profound hearing loss. To restore auditory perception, an array of micro-electrodes that deliver electrical pulses to the auditory nerve is surgically implante...
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Format: | Article |
Language: | English |
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De Gruyter
2023-12-01
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Series: | Current Directions in Biomedical Engineering |
Subjects: | |
Online Access: | https://doi.org/10.1515/cdbme-2023-1202 |
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author | Wenger Cornelia Fellner Andreas Bucek Fred Werginz Paul Rattay Frank |
author_facet | Wenger Cornelia Fellner Andreas Bucek Fred Werginz Paul Rattay Frank |
author_sort | Wenger Cornelia |
collection | DOAJ |
description | The cochlear implant was the first effective and is still the most common neuroprosthetic device which is employed for people with severe to profound hearing loss. To restore auditory perception, an array of micro-electrodes that deliver electrical pulses to the auditory nerve is surgically implanted into the lower cochlea duct, the scala tympani (ST). However, implantation into the upper cavity, the scala vestibuli (SV) has been tested due to severe anatomical obstruction or ossification of the ST. Clinical results revealed similar performance and thresholds for SV and ST cochlear implant users. We present a simulation study of auditory nerve fibre response to monophasic stimulation of both polarities. Excitation profiles are compared for microelectrodes placed in the SV and equivalent positions in the ST. In total, 7 different electrode positions for 4 different fibres have been investigated in a homogenous 2D model. Results for the intact fibres predict generally higher anodic thresholds in comparison to cathodic stimulation at the same electrode position and mostly lower thresholds for the SV electrodes in comparison to their ST counterparts. In contrast, anodic thresholds are mostly lower than cathodic thresholds for the degenerated fibres. Furthermore, due to the increased electrode-fibre distance for degenerate fibres which have completely lost the dendrite, SV stimulation is less beneficial. However, for basal fibres and the clinically relevant mid scala placement of the electrode the typically high thresholds remain similar for ST and SV positions. |
first_indexed | 2024-03-08T16:03:12Z |
format | Article |
id | doaj.art-14c3acda4f6842ce83f716fcbd2334f3 |
institution | Directory Open Access Journal |
issn | 2364-5504 |
language | English |
last_indexed | 2024-03-08T16:03:12Z |
publishDate | 2023-12-01 |
publisher | De Gruyter |
record_format | Article |
series | Current Directions in Biomedical Engineering |
spelling | doaj.art-14c3acda4f6842ce83f716fcbd2334f32024-01-08T09:53:10ZengDe GruyterCurrent Directions in Biomedical Engineering2364-55042023-12-01925810.1515/cdbme-2023-1202Simulating auditory nerve fiber response following micro-electrode stimulationWenger Cornelia0Fellner Andreas1Bucek Fred2Werginz Paul3Rattay Frank4Vienna University of Technology, Institute for Analysis and Scientific Computing, Wiedner Hauptstraße 8-10, 1040,Vienna, AustriaVienna University of Technology, Institute for Analysis and Scientific Computing,Vienna, AustriaVienna University of Technology, Institute for Analysis and Scientific Computing,Vienna, AustriaVienna University of Technology , Institute of Biomedical Electronics,Vienna, AustriaVienna University of Technology, Institute for Analysis and Scientific Computing,Vienna, AustriaThe cochlear implant was the first effective and is still the most common neuroprosthetic device which is employed for people with severe to profound hearing loss. To restore auditory perception, an array of micro-electrodes that deliver electrical pulses to the auditory nerve is surgically implanted into the lower cochlea duct, the scala tympani (ST). However, implantation into the upper cavity, the scala vestibuli (SV) has been tested due to severe anatomical obstruction or ossification of the ST. Clinical results revealed similar performance and thresholds for SV and ST cochlear implant users. We present a simulation study of auditory nerve fibre response to monophasic stimulation of both polarities. Excitation profiles are compared for microelectrodes placed in the SV and equivalent positions in the ST. In total, 7 different electrode positions for 4 different fibres have been investigated in a homogenous 2D model. Results for the intact fibres predict generally higher anodic thresholds in comparison to cathodic stimulation at the same electrode position and mostly lower thresholds for the SV electrodes in comparison to their ST counterparts. In contrast, anodic thresholds are mostly lower than cathodic thresholds for the degenerated fibres. Furthermore, due to the increased electrode-fibre distance for degenerate fibres which have completely lost the dendrite, SV stimulation is less beneficial. However, for basal fibres and the clinically relevant mid scala placement of the electrode the typically high thresholds remain similar for ST and SV positions.https://doi.org/10.1515/cdbme-2023-1202auditory nerve fibresextracellular stimulationexcitation patternscochlear implantsscala vestibuli |
spellingShingle | Wenger Cornelia Fellner Andreas Bucek Fred Werginz Paul Rattay Frank Simulating auditory nerve fiber response following micro-electrode stimulation Current Directions in Biomedical Engineering auditory nerve fibres extracellular stimulation excitation patterns cochlear implants scala vestibuli |
title | Simulating auditory nerve fiber response following micro-electrode stimulation |
title_full | Simulating auditory nerve fiber response following micro-electrode stimulation |
title_fullStr | Simulating auditory nerve fiber response following micro-electrode stimulation |
title_full_unstemmed | Simulating auditory nerve fiber response following micro-electrode stimulation |
title_short | Simulating auditory nerve fiber response following micro-electrode stimulation |
title_sort | simulating auditory nerve fiber response following micro electrode stimulation |
topic | auditory nerve fibres extracellular stimulation excitation patterns cochlear implants scala vestibuli |
url | https://doi.org/10.1515/cdbme-2023-1202 |
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