| Summary: | Molecular hybridization is one of the recent strategies to synthesize a novel hybrid compound by combining two or more pharmacophoric units. Being a linkage process, it focuses on the synthesis of hybrids which are less toxic and more potent than their parent units. Therefore, nowadays medicinal chemists look forwards for the synthesis of new novel drugs using molecular hybridization. Chalcones are a class of very important structural motifs in medicinal chemistry. Similarly, 1,2,3-triazoles are heterocyclic bio-isostere having vast spectrum of applications due to its ease of synthesis, hydrogen bond formation, inertness towards oxidizing and reducing agents, moderate dipole moment and good binding with several binding agents. In this review, we have summarized the research articles describing the medicinal application of synthetic chalcone-triazole derivatives. The structural-activity relationship has been discussed which may provide helpful guidelines for the future drug synthesis based on chalcone and triazole moieties.
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