Recent advances in chalcone-triazole hybrids as potential pharmacological agents
Molecular hybridization is one of the recent strategies to synthesize a novel hybrid compound by combining two or more pharmacophoric units. Being a linkage process, it focuses on the synthesis of hybrids which are less toxic and more potent than their parent units. Therefore, nowadays medicinal che...
| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | English |
| Publicado em: |
Elsevier
2023-12-01
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| coleção: | Results in Chemistry |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2211715623004125 |
| _version_ | 1827591169949827072 |
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| author | Akanksha Bhukal Vijay Kumar Lokesh Kumar Kashmiri Lal |
| author_facet | Akanksha Bhukal Vijay Kumar Lokesh Kumar Kashmiri Lal |
| author_sort | Akanksha Bhukal |
| collection | DOAJ |
| description | Molecular hybridization is one of the recent strategies to synthesize a novel hybrid compound by combining two or more pharmacophoric units. Being a linkage process, it focuses on the synthesis of hybrids which are less toxic and more potent than their parent units. Therefore, nowadays medicinal chemists look forwards for the synthesis of new novel drugs using molecular hybridization. Chalcones are a class of very important structural motifs in medicinal chemistry. Similarly, 1,2,3-triazoles are heterocyclic bio-isostere having vast spectrum of applications due to its ease of synthesis, hydrogen bond formation, inertness towards oxidizing and reducing agents, moderate dipole moment and good binding with several binding agents. In this review, we have summarized the research articles describing the medicinal application of synthetic chalcone-triazole derivatives. The structural-activity relationship has been discussed which may provide helpful guidelines for the future drug synthesis based on chalcone and triazole moieties. |
| first_indexed | 2024-03-09T01:28:01Z |
| format | Article |
| id | doaj.art-14c406af8add4b82b52bd6648bb2eaa4 |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-03-09T01:28:01Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-14c406af8add4b82b52bd6648bb2eaa42023-12-10T06:15:30ZengElsevierResults in Chemistry2211-71562023-12-016101173Recent advances in chalcone-triazole hybrids as potential pharmacological agentsAkanksha Bhukal0Vijay Kumar1Lokesh Kumar2Kashmiri Lal3Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, IndiaDepartment of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, IndiaDepartment of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, IndiaCorresponding author.; Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana 125001, IndiaMolecular hybridization is one of the recent strategies to synthesize a novel hybrid compound by combining two or more pharmacophoric units. Being a linkage process, it focuses on the synthesis of hybrids which are less toxic and more potent than their parent units. Therefore, nowadays medicinal chemists look forwards for the synthesis of new novel drugs using molecular hybridization. Chalcones are a class of very important structural motifs in medicinal chemistry. Similarly, 1,2,3-triazoles are heterocyclic bio-isostere having vast spectrum of applications due to its ease of synthesis, hydrogen bond formation, inertness towards oxidizing and reducing agents, moderate dipole moment and good binding with several binding agents. In this review, we have summarized the research articles describing the medicinal application of synthetic chalcone-triazole derivatives. The structural-activity relationship has been discussed which may provide helpful guidelines for the future drug synthesis based on chalcone and triazole moieties.http://www.sciencedirect.com/science/article/pii/S22117156230041251,2,3-TriazoleChalconeMolecular hybridizationCuAACStructural-activity relationship |
| spellingShingle | Akanksha Bhukal Vijay Kumar Lokesh Kumar Kashmiri Lal Recent advances in chalcone-triazole hybrids as potential pharmacological agents Results in Chemistry 1,2,3-Triazole Chalcone Molecular hybridization CuAAC Structural-activity relationship |
| title | Recent advances in chalcone-triazole hybrids as potential pharmacological agents |
| title_full | Recent advances in chalcone-triazole hybrids as potential pharmacological agents |
| title_fullStr | Recent advances in chalcone-triazole hybrids as potential pharmacological agents |
| title_full_unstemmed | Recent advances in chalcone-triazole hybrids as potential pharmacological agents |
| title_short | Recent advances in chalcone-triazole hybrids as potential pharmacological agents |
| title_sort | recent advances in chalcone triazole hybrids as potential pharmacological agents |
| topic | 1,2,3-Triazole Chalcone Molecular hybridization CuAAC Structural-activity relationship |
| url | http://www.sciencedirect.com/science/article/pii/S2211715623004125 |
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