Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect
Introduction. One of medical-social chronic consequences of diabetes mellitus is encephalopathy, with an advancing course and development of neurodegenerative disorders in the central nervous system. Objective: to examine carbacetam effect as a new modulator of gamma-aminobutyric acid activity on...
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| Format: | Article |
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Balkan Medical Union
2019-09-01
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| Series: | Archives of the Balkan Medical Union |
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| Online Access: | https://umbalk.org/wp-content/uploads/2019/09/05.PROTEIN-PEROXIDE-OXIDATION-IN-THE-CEREBRAL.pdf |
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| author | Olga G. KMET Nataliia D. FILIPETS Tamara I. HRACHOVA Yurii M. VEPRIUK Kateryna V. VLASOVA |
| author_facet | Olga G. KMET Nataliia D. FILIPETS Tamara I. HRACHOVA Yurii M. VEPRIUK Kateryna V. VLASOVA |
| author_sort | Olga G. KMET |
| collection | DOAJ |
| description | Introduction. One of medical-social chronic consequences of diabetes mellitus is encephalopathy, with an advancing course and development of neurodegenerative disorders in the central nervous system.
Objective: to examine carbacetam effect as a new modulator of gamma-aminobutyric acid activity on protein peroxide oxidation and morphological condition of the cerebral cortex and hippocampus in rats under conditions of experimental neurodegeneration in case of type 2 diabetes mellitus.
Materials and methods. Changes in the content of protein peroxide oxidation in the cerebral cortex and hippocampus under effect of carbacetam (5 mg/kg) are examined in nonlinear laboratory albino male rats with neurodegeneration under conditions of type 2 diabetes mellitus simulated by streptozotocin and high-fat diet.
Results. In rats with type 2 diabetes mellitus, the degree of protein peroxide oxidation in the cerebral cortex and hippocampus increases, which is associated with increased amount of cells with karyopyknosis, decreased relative density of staining of the neuron tigroid substance and partial denudation of vessels. After carbacetam administration during 14 days in rats with type 2 diabetes mellitus in the cerebral cortex and hippocampus the level of protein peroxide oxidation decreases, the amount of cells with karyopyknosis reduces, a relative density of staining of the neuron tigroid substance increases, and denudation of vessels is lacking.
Conclusions. Decreased intensity of the protein peroxide oxidation processes, histological destruction of the cerebral cortex and hippocampus are indicative of a neuroprotective potential of carbacetam under conditions of neurodegeneration caused by type 2 diabetes mellitus. |
| first_indexed | 2024-12-12T01:55:28Z |
| format | Article |
| id | doaj.art-14c426d3babb41f2810b3bbe0ed32d07 |
| institution | Directory Open Access Journal |
| issn | 1584-9244 2558-815X |
| language | English |
| last_indexed | 2024-12-12T01:55:28Z |
| publishDate | 2019-09-01 |
| publisher | Balkan Medical Union |
| record_format | Article |
| series | Archives of the Balkan Medical Union |
| spelling | doaj.art-14c426d3babb41f2810b3bbe0ed32d072022-12-22T00:42:22ZengBalkan Medical UnionArchives of the Balkan Medical Union1584-92442558-815X2019-09-01543431437Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effectOlga G. KMET0Nataliia D. FILIPETS1Tamara I. HRACHOVA2Yurii M. VEPRIUK3Kateryna V. VLASOVA4Higher State Educational Establishment of Ukraine „Bukovinian State Medical University“, Chernivtsi, UkraineHigher State Educational Establishment of Ukraine „Bukovinian State Medical University“, Chernivtsi, UkraineHigher State Educational Establishment of Ukraine „Bukovinian State Medical University“, Chernivtsi, UkraineHigher State Educational Establishment of Ukraine „Bukovinian State Medical University“, Chernivtsi, UkraineHigher State Educational Establishment of Ukraine „Bukovinian State Medical University“, Chernivtsi, UkraineIntroduction. One of medical-social chronic consequences of diabetes mellitus is encephalopathy, with an advancing course and development of neurodegenerative disorders in the central nervous system. Objective: to examine carbacetam effect as a new modulator of gamma-aminobutyric acid activity on protein peroxide oxidation and morphological condition of the cerebral cortex and hippocampus in rats under conditions of experimental neurodegeneration in case of type 2 diabetes mellitus. Materials and methods. Changes in the content of protein peroxide oxidation in the cerebral cortex and hippocampus under effect of carbacetam (5 mg/kg) are examined in nonlinear laboratory albino male rats with neurodegeneration under conditions of type 2 diabetes mellitus simulated by streptozotocin and high-fat diet. Results. In rats with type 2 diabetes mellitus, the degree of protein peroxide oxidation in the cerebral cortex and hippocampus increases, which is associated with increased amount of cells with karyopyknosis, decreased relative density of staining of the neuron tigroid substance and partial denudation of vessels. After carbacetam administration during 14 days in rats with type 2 diabetes mellitus in the cerebral cortex and hippocampus the level of protein peroxide oxidation decreases, the amount of cells with karyopyknosis reduces, a relative density of staining of the neuron tigroid substance increases, and denudation of vessels is lacking. Conclusions. Decreased intensity of the protein peroxide oxidation processes, histological destruction of the cerebral cortex and hippocampus are indicative of a neuroprotective potential of carbacetam under conditions of neurodegeneration caused by type 2 diabetes mellitus.https://umbalk.org/wp-content/uploads/2019/09/05.PROTEIN-PEROXIDE-OXIDATION-IN-THE-CEREBRAL.pdftype 2 diabetes mellitusneurodegenerationcarbacetamprotein oxidation modification |
| spellingShingle | Olga G. KMET Nataliia D. FILIPETS Tamara I. HRACHOVA Yurii M. VEPRIUK Kateryna V. VLASOVA Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect Archives of the Balkan Medical Union type 2 diabetes mellitus neurodegeneration carbacetam protein oxidation modification |
| title | Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect |
| title_full | Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect |
| title_fullStr | Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect |
| title_full_unstemmed | Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect |
| title_short | Protein peroxide oxidation in the cerebral cortex and hippocampus of rats with Type 2 diabetes mellitus, under carbacetam effect |
| title_sort | protein peroxide oxidation in the cerebral cortex and hippocampus of rats with type 2 diabetes mellitus under carbacetam effect |
| topic | type 2 diabetes mellitus neurodegeneration carbacetam protein oxidation modification |
| url | https://umbalk.org/wp-content/uploads/2019/09/05.PROTEIN-PEROXIDE-OXIDATION-IN-THE-CEREBRAL.pdf |
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