Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells

Loss of PIKfyve Causes Transdifferentiation of Dictyostelium Spores Into Basal Disc Cells

The 1-phosphatidylinositol-3-phosphate 5-kinase PIKfyve generates PtdIns3,5P2 on late phagolysosomes, which by recruiting the scission protein Atg18, results in their fragmentation in the normal course of endosome processing. Loss of PIKfyve function causes cellular hypervacuolization in eukaryotes...

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Bibliographic Details
Main Authors:	Yoko Yamada, Gillian Forbes, Qingyou Du, Takefumi Kawata, Pauline Schaap
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	1-phosphatidylinositol-3-phosphate 5-kinase Atg18 Vac14 membrane scission vesicle trafficking cell-type specific gene expression
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2021.692473/full

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