Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications
Considering the rising global health challenges and public expectations in terms of safety and cost effectiveness, it is necessary to promote effective, safer and cheaper alternative treatment options, particularly to benefit low- and middle-income countries (LMICs). Therapeutic regimens implying na...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522001440 |
| _version_ | 1828269096496529408 |
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| author | Firdaus Jahan Sahir Sultan Alvi Mohammad Hayatul Islam |
| author_facet | Firdaus Jahan Sahir Sultan Alvi Mohammad Hayatul Islam |
| author_sort | Firdaus Jahan |
| collection | DOAJ |
| description | Considering the rising global health challenges and public expectations in terms of safety and cost effectiveness, it is necessary to promote effective, safer and cheaper alternative treatment options, particularly to benefit low- and middle-income countries (LMICs). Therapeutic regimens implying natural sources i.e., plants and their secondary metabolites have been trusted by a large proportion of sufferers and extensively searched for their pharmacological actions. Berberis aristata, commonly known as Zarishk, Daruharidra and Indian barberry, is being used in traditional medicine systems across the globe, particularly Asian countries i.e., India and China, and has also gained much attention in the current era of modern medicine. The protective effects of B. aristata against a number of diseases are attributed to its bioactive metabolites, mostly alkaloids, including berberine, berbamine, aromoline, jatrorrhizine, oxyberberine, palmatine, tetrahydropalmatine, and lupeol. However, a comprehensive report describing the ethnopharmacological relevance, important secondary metabolites, cytotoxicity, and recent advances in its therapeutic efficacy against various ailments is either outdated or still lacking. Therefore, the current review summarizes the recent updates regarding the implications of B. aristata and its potential bioactive secondary metabolites in targeting various acute and chronic diseases including diabetes, cardiovascular complications, cancer, hepatic dysfunction, infectious diseases, oxidative stress, inflammation, neurodegeneration, and ageing-associated symptoms with special emphasis on the biochemical and molecular mechanisms/pathways. |
| first_indexed | 2024-04-13T05:26:21Z |
| format | Article |
| id | doaj.art-14c6fe02ece742259f49ea982960ee99 |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-04-13T05:26:21Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-14c6fe02ece742259f49ea982960ee992022-12-22T03:00:34ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-12-015100184Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applicationsFirdaus Jahan0Sahir Sultan Alvi1Mohammad Hayatul Islam2Department of Biosciences, Faculty of Science, IIRC-5, Clinical Biochemistry and Natural Product Research Lab, Integral University, Lucknow, Uttar Pradesh 226026, IndiaCorresponding authors.; Department of Biosciences, Faculty of Science, IIRC-5, Clinical Biochemistry and Natural Product Research Lab, Integral University, Lucknow, Uttar Pradesh 226026, IndiaCorresponding authors.; Department of Biosciences, Faculty of Science, IIRC-5, Clinical Biochemistry and Natural Product Research Lab, Integral University, Lucknow, Uttar Pradesh 226026, IndiaConsidering the rising global health challenges and public expectations in terms of safety and cost effectiveness, it is necessary to promote effective, safer and cheaper alternative treatment options, particularly to benefit low- and middle-income countries (LMICs). Therapeutic regimens implying natural sources i.e., plants and their secondary metabolites have been trusted by a large proportion of sufferers and extensively searched for their pharmacological actions. Berberis aristata, commonly known as Zarishk, Daruharidra and Indian barberry, is being used in traditional medicine systems across the globe, particularly Asian countries i.e., India and China, and has also gained much attention in the current era of modern medicine. The protective effects of B. aristata against a number of diseases are attributed to its bioactive metabolites, mostly alkaloids, including berberine, berbamine, aromoline, jatrorrhizine, oxyberberine, palmatine, tetrahydropalmatine, and lupeol. However, a comprehensive report describing the ethnopharmacological relevance, important secondary metabolites, cytotoxicity, and recent advances in its therapeutic efficacy against various ailments is either outdated or still lacking. Therefore, the current review summarizes the recent updates regarding the implications of B. aristata and its potential bioactive secondary metabolites in targeting various acute and chronic diseases including diabetes, cardiovascular complications, cancer, hepatic dysfunction, infectious diseases, oxidative stress, inflammation, neurodegeneration, and ageing-associated symptoms with special emphasis on the biochemical and molecular mechanisms/pathways.http://www.sciencedirect.com/science/article/pii/S2667142522001440Berberis aristataEthnopharmacological relevanceBioactive secondary metabolitesToxicityNutraceutical applicationsMolecular mechanisms |
| spellingShingle | Firdaus Jahan Sahir Sultan Alvi Mohammad Hayatul Islam Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications Pharmacological Research - Modern Chinese Medicine Berberis aristata Ethnopharmacological relevance Bioactive secondary metabolites Toxicity Nutraceutical applications Molecular mechanisms |
| title | Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications |
| title_full | Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications |
| title_fullStr | Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications |
| title_full_unstemmed | Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications |
| title_short | Berberis aristata and its secondary metabolites: Insights into nutraceutical and therapeutical applications |
| title_sort | berberis aristata and its secondary metabolites insights into nutraceutical and therapeutical applications |
| topic | Berberis aristata Ethnopharmacological relevance Bioactive secondary metabolites Toxicity Nutraceutical applications Molecular mechanisms |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522001440 |
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