The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer
The management of muscle invasive bladder cancer represents an unresolved clinical challenge. Invasive urothelial carcinomas are associated with high mortality rates and early metastatic disease. Radical cystectomy is a recognized standard of care, although disease-free survival outcomes remain subo...
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2014-10-01
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| Series: | International Journal of Medical Students |
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| Online Access: | http://ijms.info/IJMS/article/view/101 |
| _version_ | 1827851454858133504 |
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| author | Joshua Luck |
| author_facet | Joshua Luck |
| author_sort | Joshua Luck |
| collection | DOAJ |
| description | The management of muscle invasive bladder cancer represents an unresolved clinical challenge. Invasive urothelial carcinomas are associated with high mortality rates and early metastatic disease. Radical cystectomy is a recognized standard of care, although disease-free survival outcomes remain suboptimal. The limitations of pre-operative clinical staging, as well as the complex natural history of the disease, precludes the introduction of simple management protocols. To what degree chemotherapy and radiotherapy may be useful in the surgical management of invasive bladder cancer remains contentious. This literature review critically examines the benefits, risks and difficulties of each approach, with an emphasis on individually tailored therapy. |
| first_indexed | 2024-03-12T10:32:22Z |
| format | Article |
| id | doaj.art-14c7fe5d146c4ab6b1ec177e9ed0744a |
| institution | Directory Open Access Journal |
| issn | 2076-6327 |
| language | English |
| last_indexed | 2024-03-12T10:32:22Z |
| publishDate | 2014-10-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | International Journal of Medical Students |
| spelling | doaj.art-14c7fe5d146c4ab6b1ec177e9ed0744a2023-09-02T09:05:17ZengUniversity Library System, University of PittsburghInternational Journal of Medical Students2076-63272014-10-012312513110.5195/ijms.2014.101101The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder CancerJoshua Luck0Medical Student, University of Oxford, United KingdomThe management of muscle invasive bladder cancer represents an unresolved clinical challenge. Invasive urothelial carcinomas are associated with high mortality rates and early metastatic disease. Radical cystectomy is a recognized standard of care, although disease-free survival outcomes remain suboptimal. The limitations of pre-operative clinical staging, as well as the complex natural history of the disease, precludes the introduction of simple management protocols. To what degree chemotherapy and radiotherapy may be useful in the surgical management of invasive bladder cancer remains contentious. This literature review critically examines the benefits, risks and difficulties of each approach, with an emphasis on individually tailored therapy.http://ijms.info/IJMS/article/view/101chemoradiotherapycombined modality therapyurinary bladder neoplasmscystectomy |
| spellingShingle | Joshua Luck The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer International Journal of Medical Students chemoradiotherapy combined modality therapy urinary bladder neoplasms cystectomy |
| title | The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer |
| title_full | The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer |
| title_fullStr | The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer |
| title_full_unstemmed | The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer |
| title_short | The Role of Chemotherapy and Radiotherapy in the Surgical Management of Muscle Invasive Bladder Cancer |
| title_sort | role of chemotherapy and radiotherapy in the surgical management of muscle invasive bladder cancer |
| topic | chemoradiotherapy combined modality therapy urinary bladder neoplasms cystectomy |
| url | http://ijms.info/IJMS/article/view/101 |
| work_keys_str_mv | AT joshualuck theroleofchemotherapyandradiotherapyinthesurgicalmanagementofmuscleinvasivebladdercancer AT joshualuck roleofchemotherapyandradiotherapyinthesurgicalmanagementofmuscleinvasivebladdercancer |